高光热效应碳球的快速制备及肿瘤细胞光热治疗  

Carbon Spheres for Photothermal Therapy of Tumor Cells:Rapid Preparation and High Photothermal Effect

作　　者：魏成雄 金鑫[1] 殷培楠 吴承伟[1] 张伟[1] WEI Chengxiong;JIN Xin;YIN Peinan;WU Chengwei;ZHANG Wei(Laboratory of Biology and Nanomechanics,Department of Engineering Mechanics,State Key Laboratory of Structural Analysis for Industrial Equipment,Dalian University of Technology,Dalian 116024,China)

机构地区：[1]大连理工大学工业装备结构分析国家重点实验室,工程力学系,生物与纳米力学实验室,大连116024

出　　处：《无机材料学报》2021年第11期1208-1216,共9页Journal of Inorganic Materials

基　　金：国家重点研发计划项目(2018YFA0704103,2018YFA0704104);辽宁省自然科学基金项目(2019-KF-02-01);中央高校基本科研业务费项目(DUT21TD105,DUT20YG129)。

摘　　要：光热治疗是一种非侵入式的新型肿瘤治疗手段,可弥补传统治疗方式的不足。碳纳米材料作为一种高效的光热剂,在肿瘤光热治疗中表现出巨大的应用潜力。本研究采用超声辅助法使邻苯三酚与甲醛5 min快速聚合,经煅烧处理制备了单分散、粒径均一的碳球。该碳球兼具优良的细胞生物相容性和高光热转换效率。在808 nm近红外光照射下,碳球呈现良好的光热效应和光热稳定性,光热转换效率达到41.4%。细胞实验表明,碳球无明显细胞毒性,对肿瘤细胞具有显著的光热杀伤效果。制备的高光热效应碳球光热剂有望用于肿瘤光热治疗。Photothermal therapy is a new non-invasive treatment method,which can make up for the deficiency of traditional tumor therapy.As an efficient photothermal agent,carbon nanomaterials show great potential in the photothermal therapy of tumor.In this study,a rapid polymerization of pyrogallic acid and formaldehyde was induced by ultrasound-assisted method.Carbon spheres with good biocompatibility and high photothermal conversion efficiency were quickly prepared by subsequent calcination treatment.The prepared carbon spheres are highly monodisperse and uniform in size.Under 808 nm near-infrared light irradiation,they exhibit good photothermal effect and photothermal stability with photothermal conversion efficiency up to 41.4%.Cell experiments show that carbon spheres have no obvious cytotoxicity,and can effectively kill the tumor cells under near-infrared light irradiation.This work is expected to construct efficient photothermal carbon spheres for photothermal therapy of tumor.

关 键 词：超声辅助法 碳球 光热治疗 肿瘤 

分 类 号：TB34[一般工业技术—材料科学与工程]