生物支架材料促进骨髓间充质干细胞成骨分化的研究热点  

Research hotspot of biological scaffold materials promoting osteogenic differentiation of bone marrow mesenchymal stem cells

作　　者：康坤龙 王新涛[1] Kang Kunlong;Wang Xintao(Department of Orthopedics,The 2^(nd) Affiliated Hospital of Harbin Medical University,Harbin 150001,Heilongjiang Province,China)

机构地区：[1]哈尔滨医科大学附属第二医院骨科,黑龙江省哈尔滨市150001

出　　处：《中国组织工程研究》2022年第4期597-603,共7页Chinese Journal of Tissue Engineering Research

基　　金：国家自然科学基金(81772362),项目负责人:王新涛。

摘　　要：背景:目前单一生物支架材料难以满足骨组织工程的成骨需要,骨髓间充质干细胞具有优良的成骨特点,复合支架材料及复合生长因子的支架具有更优良的成骨能力,是目前研究的热点。目的:对不同生物支架材料及其改型后促进骨髓间充质干细胞成骨分化进行综述。方法:由第一作者通过检索中国知网、万方、维普、PubMed、Embase数据库2014年1月至2020年7月发表的相关文献,检索词为"骨髓间充质干细胞,支架,成骨分化,羟基磷灰石,胶原,壳聚糖;Bone marrow mesenchymal stem cells,scaffold,osteogenic,hydroxyapatite,collagen,chitosan",最终选取符合标准的文献69篇。结果与结论:骨组织工程的飞速发展可有效解决骨缺损修复的难题,种子细胞和生物支架材料是骨组织工程的核心内容。骨髓间充质干细胞具有优良的成骨分化能力,被广泛应用于骨组织工程。将不同的支架材料复合,利用先进的制备工艺或者进行支架的表面修饰、添加生长因子等可充分结合各种生物支架材料的优点,诱导骨髓间充质干细胞的成骨分化和支架血管的形成,达到修复骨缺损的目的,是骨组织工程的研究热点。BACKGROUND: At present, a single biological scaffold material is difficult to meet the osteogenic needs of bone tissue engineering, and bone marrow mesenchymal stem cells have excellent osteogenic characteristics. Composite scaffolds and scaffolds combined with growth factors have better osteogenic ability. It is a research hotspot at present.OBJECTIVE: To review different biological scaffolds and their modified scaffolds to promote the osteogenic differentiation of bone marrow mesenchymal stem cells.METHODS: The related articles published in CNKI, Wanfang, VIP, PubMed and Embase databases from January 2014 to July 2020 were searched by the first author with the keywords of "bone marrow mesenchymal stem cells, scaffolds, osteogenic differentiation, hydroxyapatite, collagen, chitosan" in English and Chinese. Finally, 69 articles were selected. RESULTS AND CONCLUSION: The rapid development of bone tissue engineering can effectively solve the problem of bone defect repair. Seed cells and biological scaffold materials are the core of bone tissue engineering. Bone marrow mesenchymal stem cells have excellent osteogenic differentiation ability and are widely used in bone tissue engineering. The combination of different scaffold materials, the use of advanced preparation technology, or the surface modification of scaffolds and the addition of growth factors can fully combine the advantages of various biological scaffold materials, induce the osteogenic differentiation of bone marrow mesenchymal stem cells and the formation of scaffold blood vessels, and achieve the purpose of repairing bone defects, and is the research focus of bone tissue engineering.

关 键 词：骨 材料 骨组织工程 骨髓间充质干细胞 支架材料 成骨 羟基磷灰石 明胶 生物活性玻璃 钛金属 综述 

分 类 号：R459.9[医药卫生—治疗学] R329.2[医药卫生—临床医学]