静电纺丝技术在肩袖损伤修复中的应用  

Electrospinning for rotator cuff repair

作　　者：高仓健 杨振 刘舒云[1] 李浩[1,2] 付力伟 赵天元 陈威 廖志垚[1,2] 李品学 眭翔 郭全义 Gao Cangjian;Yang Zhen;Liu Shuyun;Li Hao;Fu Liwei;Zhao Tianyuan;Chen Wei;Liao Zhiyao;Li Pinxue;Sui Xiang;Guo Quanyi(Institute of Orthopedics,the First Medical Center,Chinese PLA General Hospital,Beijing Key Laboratory of Regenerative Medicine in Orthopedics,Key Laboratory of Musculoskeletal Trauma&War Injuries,PLA,Beijing 100853,China;Medical College of Nankai University,Tianjin 300071,China)

机构地区：[1]解放军总医院第一医学中心骨科研究所,骨科再生医学北京市重点实验室,全军骨科战创伤重点实验室,北京市100853 [2]南开大学医学院,天津市300071

出　　处：《中国组织工程研究》2022年第4期637-642,共6页Chinese Journal of Tissue Engineering Research

基　　金：国家重点研发计划课题(2019YFA0110600),项目负责人:郭全义。

摘　　要：背景:应用静电纺丝技术制备的纳米纤维结构与天然肌腱组织细胞外基质相似,并具有纳米纤维本身的固有特性。目的:综述各类静电纺丝支架的构成方式及其在肌腱和肩袖组织工程中的应用。方法:通过中国知网、万方、Pub Med、Web of Science数据库进行在线文献检索,检索时间范围为2000-2020年。中、英文关键词为"静电纺丝,纳米纤维,肌腱,肩袖,组织工程;electrospun or electrospinning,nanofibers,tendon,rotator cuff,tissue engineering",纳入与静电纺丝、肩袖、肌腱及组织工程有关的文章,最终对69篇文献进行分析。结果与结论:静电纺丝的支架构建在材料选择、纤维构成及改性与载药上的策略多种多样。天然材料与合成材料各有优势,两种及以上材料的混合电纺能产生独特的性质。非取向纤维具有更好的拉伸长度,取向纤维在弹性模量、断裂强度及生物相容性上均具有优势。改性、载药等手段均能使纳米纤维支架获得特殊的性质,有助于肩袖和肌腱损伤修复。BACKGROUND: The structure of nanofibers prepared by electrospinning technology is similar to that of natural tendon tissue and extracellular matrix, and has the inherent characteristics of nanofibers.OBJECTIVE: To review the structure of various electrospinning scaffolds and their application in tendon and rotator cuff tissue engineering systematically.METHODS: Pub Med, CNKI, Wanfang, and Web of Science databases were searched for relevant articles published from 2000 to 2020 with the search terms of "electrospun, tendon, rotator cuff, tissue engineering" in both English and Chinese. Totally 69 articles were finally included for analysis.RESULTS AND CONCLUSION: There are various strategies in manufacturing electrospun scaffolds. Scaffolds differ from material selection, fiber composition, modification and drug loading and many other aspects. Natural and synthetic materials both have their own advantages. Hybrid electrospinning of more than two kinds of materials can produce unique properties. Although non-aligned fibers have better tensile length, aligned fibers have advantages in elastic modulus, fracture strength and biocompatibility. Nanofibrous scaffolds can also be used in drug release, and it may have a modified characteristic and improve rotator cuff and tendon healing.

关 键 词：骨 材料 静电纺丝 纳米纤维 组织工程 肩袖 肌腱 综述 

分 类 号：R459.9[医药卫生—治疗学] R318.08[医药卫生—临床医学]