Effect of traditional Chinese preparation Xuebijing on inflammatory markers in patients with ventilator-associated pneumonia  

作　　者：Hong-wei Zhang Li-you Wei Ji-xuan Wang Shu-zheng Liu Dan Xing Rui Zhang Hui Guo Li-juan Chen Jing Zhang 

机构地区：[1]Intensive Care Unit and Orthopaedics,the Second Hospital of Tangshan(Orthopaedic Hospital Affiliated to North China University of Science and Technology),Tangshan 063000,China [2]Intensive Care Unit,the People's Hospital of Tangshan,Tangshan 063000,China

出　　处：《Journal of Acute Disease》2021年第5期216-220,共5页急性病杂志（英文版）

基　　金：This work was supported by the Talent Funding Project of Tangshan City in Hebei Province(No.a201902005).

摘　　要：Objective:To observe the effect of Xuebijing,a complex traditional Chinese preparation,on inflammation and prognosis of patients with pneumonia.Methods:The patients with ventilator-associated pneumonia in the intensive care unit(ICU)were randomly divided into the control group and the treatment group with 35 cases in each group.Both groups were given routine treatment such as anti-inflammatory drugs,rehydration,expectorant,and nutritional support,while the treatment group was additionally given Xuebijing injection.Serum C-reactive protein(CRP),clinical pulmonary infection score(CPIS),acute physiology,and chronic health scoreⅡ(APACHEⅡ)were recorded before treatment,the 3rd and 7th day after treatment.The duration of antibiotic use,mechanical ventilation,ICU stay,and mortality during 28 days was recorded.Results:There was no significant difference in CRP,CPIS,and APACHEⅡbetween the two groups before treatment(P>0.05).The improvement of CRP,CPIS,and APACHEⅡin the treatment group was better than those in the control group on the 3 and 7 days after treatment,and the differences were statistically significant(P<0.05).The duration of antibiotic use,mechanical ventilation,and ICU stay in the treatment group were less than those in the control group(P<0.05).The 28-day mortality of the treatment group was lower than that of the control group,but the difference was not statistically significant(P>0.05).Conclusions:Xuebijing injection can improve the inflammatory indexes of patients with ventilator-associated pneumonia,and can partly improve the prognosis.

关 键 词：Xuebijing injection Ventilator-associated pneumonia C-reactive protein Clinical pulmonary infection score APACHEⅡ 

分 类 号：R56[医药卫生—呼吸系统]