组胺H3受体在精神分裂症阴性症状和认知功能中的研究进展  

The progress on the effect of histaminergic H3 receptor on negative symptoms and cognitive function of schizophrenia

作　　者：吕钦谕(综述) 陆佳晶[1] 易正辉(审校) LYU Qin-yu;LU Jia-jing;YI Zheng-hui(Department of Psychiatry,Huashan Hospital,Fudan University,Shanghai 200040,China;Department of Psychiatry,Shanghai Mental Health Centre,Shanghai Jiao Tong University School of Medicine,Shanghai 200030,China)

机构地区：[1]复旦大学附属华山医院精神医学科,上海200040 [2]上海交通大学医学院附属精神卫生中心普通精神科,上海200030

出　　处：《复旦学报（医学版）》2021年第6期834-840,共7页Fudan University Journal of Medical Sciences

基　　金：上海市“科技创新行动计划”自然科学基金(21ZR1455400);上海交通大学“交大之星”计划医工交叉研究基金(YG2019QNB07);江苏省科技计划项目重点研发计划(BE2020661)~~

摘　　要：精神分裂症是一种严重的神经精神障碍,阴性症状和认知功能是精神分裂症的核心症状,其发病机制与各种神经递质系统的失调有关。组胺H3受体及拮抗剂在中枢神经系统中发挥独特且关键的作用,可以作为重要的药物干预靶点。目前,H3受体拮抗剂/反向激动剂对改善精神疾病的阴性症状和认知功能的结论不一致。因此,本文对组胺能H3受体及其拮抗剂在精神分裂症阴性症状和认知功能中的作用作一阐述,并对H3受体及其拮抗剂在精神分裂症阴性症状和认知功能治疗中的潜在用途进行展望。Schizophrenia is a severe neuropsychiatric disorder with the core symptoms of negative symptoms and cognitive functioning,the pathogenesis of which is associated with dysregulation of various neurotransmitter systems.Histamine H3 receptors and antagonists play a unique and critical role in the central nervous system and can serve as potent targets for pharmacological intervention.Currently,there are inconsistent findings on the effects of H3 receptor antagonists/inverse agonists on improving negative symptoms and cognitive function in schizophrenia.Therefore,this article provides an account of the role of histaminergic H3 receptors and their antagonists in negative symptoms and cognitive function in schizophrenia.An outlook on the potential use of H3 receptors and their antagonists in the treatment of negative symptoms and cognitive function in schizophrenia.

关 键 词：精神分裂症 组胺H3受体 H3拮抗剂/反向激动剂 阴性症状 认知功能 

分 类 号：R373[医药卫生—病原生物学] Q782[医药卫生—基础医学]