血细胞参数在IgM抗体阳性儿童支原体肺炎中的应用  

Application of blood cell parameters in Mycoplasma pneumonia of IgM positive children

作　　者：朱松涛 邹旭美 杨华莹 陆焱 刘鸿生 ZHU Songtao;ZOU Xumei;YANG Huaying;LU Yan;LIU Hongsheng(Department of Clinical Laboratory,Wuxi Peoples’Hospital Affiliated to Nanjing Medical University,Wuxi,Jiangsu,214023,China)

机构地区：[1]南京医科大学附属无锡人民医院医学检验科,江苏无锡214023

出　　处：《当代医学》2021年第34期9-12,共4页Contemporary Medicine

摘　　要：目的探讨血细胞参数在IgM抗体阳性儿童肺炎支原体感染中的应用价值。方法选取2019年9月1日-30日于无锡市儿童医院就诊的52例IgM抗体阳性支原体肺炎患儿作为病例组,另选取同期年龄、性别相匹配的59名健康体检儿童作为对照组。检测两组外周血细胞参数,分析两组指标差异变化及其在儿童支原体肺炎中的临床应用价值。结果病例组白细胞(WBC)、中性粒细胞比例(NE)、中性粒细胞计数(NE#)、淋巴细胞计数(LY#)、红细胞分布宽度(RDW)、C反应蛋白(CRP)均明显高于对照组,淋巴细胞比例(LY)、嗜酸粒细胞比例(EO)、嗜酸粒细胞计数(EO#)、血小板计数(PLT)、血小板压积(PCT)、血红蛋白(Hb)均明显低于对照组,差异有统计学意义(P<0.05)。WBC、NE、NE#、CRP、RDW、EO、EO#、LY、Hb、PCT、PLT在诊断儿童支原体肺炎中的受试者工作特征曲线下面积(AUC)比较差异有统计学意义(P<0.05),其中EO、RDW、PCT的AUC分别为0.806、0.797、0.780。Cut-off取值下,PCT的诊断灵敏度(0.731)最高,WBC的诊断特异度(0.966)最高。结论支原体肺炎患儿血细胞参数表现为EO、RDW、PCT指标显著异常,其中PCT、WBC的诊断价值较高,可作为辅助诊断支原体肺炎的潜在指标,但可靠性有待进一步考证。Objective To explore the application value of blood cell parameters in Mycoplasma pneumoniae infection of IgM positive children.Methods 52 children with IgM positive Mycoplasma pneumonia who were treated in Wuxi Children’ s Hospital from September 1-30, 2019 were selected as the case group, and 59 healthy children with matching age and sex during the same period were selected as the control group. Detect the peripheral blood cell parameters of the two groups, analyze the difference of indicators and their clinical application value in childhood Mycoplasma pneumonia between the two groups. Results The white blood cell(WBC), neutrophil(NE), neutrophil count(NE#), lymphocyte count(LY#), red blood cell distribution width(RDW), and C-reactive protein(CRP) in the case group were significantly higher than those in the control group, the ratio of lymphocytes(LY), eosinophil ratio(EO), eosinophil count(EO#), platelet count(PLT), platelet packed volume(PCT), and hemoglobin(Hb)were significantly lower than the control group, the difference was statistically significant(P<0.05). The area under the receiver operating characteristic curve(AUC) of WBC, NE, NE#, CRP, RDW, EO, EO#, LY, Hb, PCT, PLT in the diagnosis of mycoplasma pneumonia in children was statistically significant(P<0.05), and the AUC of EO, RDW, and PCT were 0.806, 0.797, 0.780, respectively. Under the Cut-off value, PCT has the highest diagnostic sensitivity(0.731), and WBC has the highest diagnostic specificity(0.966). Conclusion The blood cell parameters of children with Mycoplasma pneumonia showed significant abnormalities in EO, RDW and PCT. Among them, PCT and WBC had higher diagnostic value, which could be used as potential indicators for auxiliary diagnosis of Mycoplasma pneumonia, but the reliability needed further research.

关 键 词：支原体肺炎 儿童 血细胞 受试者工作特征曲线 

分 类 号：R725.6[医药卫生—儿科]