嗜酸性粒细胞与特发性肺纤维化关系的研究进展  

Relationship between eosinophils and idiopathic pulmonary fibrosis

作　　者：韩闪 刘晓秋[1] HAN Shan;LIU Xiao-qiu(Department of Respiratory and Critical Care,the Second Hospital of Jilin University,Changchun,Jilin 130000,China)

机构地区：[1]吉林大学第二医院呼吸与危重症医学科,吉林长春130000

出　　处：《中华实用诊断与治疗杂志》2021年第11期1182-1184,共3页Journal of Chinese Practical Diagnosis and Therapy

基　　金：吉林省科技厅自然科学基金资助项目(20160101089JC);吉林省卫生计生科研计划课题(20152020)。

摘　　要：特发性肺纤维化(idiopathic pulmonary fibrosis,IPF)患者支气管肺泡灌洗液中嗜酸性粒细胞约占30%,超过中性粒细胞;肺组织活检标本常发现肺间质和肺泡内嗜酸性粒细胞增多。肺纤维化发病中嗜酸性粒细胞可能发挥一定作用,且支气管肺泡灌洗液中嗜酸性粒细胞增多提示治疗反应差、生存时间短。但有关嗜酸性粒细胞与IPF关系的报道较少。本文就嗜酸性粒细胞及其与IPF急性加重、肺功能、影像学、预后关系的研究进展作一综述。Eosinophils account for about 30%of bronchoalveolar lavage fluid in patients with idiopathic pulmonary fibrosis(IPF),more than neutrophils.In lung biopsy specimens from patients with IPF,eosinophils increase in the interstitium and alveoli.Eosinophils may be involved in the pathogenesis of pulmonary fibrosis,and the increased eosinophils in bronchoalveolar lavage fluid suggest a poor treatment response and short survival time.Few reports were on the relationship between eosinophils and IPF.This paper reviews the research progress of the role of eosinophils in IPF,and the relationships of eosinophils with acute exacerbation of IPF,lung function,imaging and prognosis.

关 键 词：特发性肺纤维化 嗜酸性粒细胞 肺功能 影像学 预后 

分 类 号：R563.9[医药卫生—呼吸系统]