头顶一颗珠对子宫平滑肌收缩的作用  

Effect of Trillium tschonoskii Maxim.on the Contraction of Uterine Smooth Muscle

作　　者：王晓珍 刘录 吴安超 王钺涵 周志宏 杨竹雅 WANG Xiao-zhen;LIU Lu;WU An-chao;WANG Yue-han;ZHOU Zhi-hong;YANG Zhu-ya(Engineering Research Center for Chinese Herbal Pieces of Yunnan University of TCM,Kunming Yunnan 650500,China)

机构地区：[1]云南中医药大学云南省高校中药饮片工程研究中心,云南昆明650500

出　　处：《昆明医科大学学报》2021年第11期9-13,共5页Journal of Kunming Medical University

基　　金：云南省重大科技专项计划(生物医药)资助项目(2017ZF011)。

摘　　要：目的研究头顶一颗珠(Trillium tschonoskii Maxim.)的子宫平滑肌收缩作用及其物质基础。方法运用大鼠离体子宫平滑肌试验方法,对头顶一颗珠分离后的不同馏分进行活性筛选,采用现代波谱技术鉴定有效部位的主要成分。结果筛选出头顶一颗珠引起子宫平滑肌收缩的活性部位,并鉴定了其3个主要成分,均为偏诺皂苷。结论头顶一颗珠具有显著的子宫平滑肌收缩作用,该作用的活性成分为偏诺皂苷。Objective To study the chemical constituents of the rhizomes of Trillium tschonoskii that cause uterine smooth muscle contraction.Methods The isolated rat uterine smooth muscle test method was used to screen the activity of different extracted parts of Trillium tschonoskii.Modern spectroscopy techniques were used to identify the main components of the effective parts.Results The main active part of T.tschonoskii that caused uterine smooth muscle contraction was screened,and three main components were identified as pennogenin saponins from this part.Conclusion T.tschonoskii has the effect of inducing uterine smooth muscle contraction,and the main active ingredient of this effect was pennogenin saponins.

关 键 词：头顶一颗珠 子宫平滑肌 化学成分 偏诺皂苷 

分 类 号：R282[医药卫生—中药学]