二维超声评估孕龄、双顶径与胎儿甲状腺大小相关性  

Correlation between Gestational Age,Biparietal Diameter and Fetal Thyroid Estimated by the 2-Dimensional Sonography

作　　者：李秀玲[1] 董旭东[1] 刘焕玲[1] 颜芳[1] 侯晴沙 陈醇 LI Xiu-ling;DONG Xu-dong;LIU Huan-ling;YAN Fang;HOU Qing-sha;CHEN Chun(Dept.of Obstetrics,the First People’s Hospital of Yunnan Province/Affiliated Hospital of Kunming University of Science and Technology,Kunming Yunnan 650032,China)

机构地区：[1]云南省第一人民医院/昆明理工大学附属医院产科,云南昆明650032

出　　处：《昆明医科大学学报》2021年第11期45-50,共6页Journal of Kunming Medical University

基　　金：云南省院士专家工作站(202005AF15033);云南省卫生健康委员会高级人才项目(L-2018006);云南省科技厅-昆明医科大学联合专项基金项目(202001AY070001-123);云南省医疗卫生单位内设研究机构科研项目(2018NS0240)。

摘　　要：目的利用经腹部二维超声探讨胎儿不同孕周、双顶径与甲状腺大小相关性的研究,建立胎儿甲状腺正常参考范围,用于临床评估胎儿甲状腺功能。方法对740名妊娠20~38周的健康孕妇进行测量胎儿甲状腺直径、周长及面积,计算5th、50th、95th百分位数,分析其分别与孕周、双顶径的相关性。结果获得20~38周胎儿甲状腺的直径、周长及面积的正常参考范围,发现其第5th、50th、95th百分位数分别随孕龄增加而增大,与孕龄呈高度相关性,相关系数r分别为0.909、0.904、0.913,差异有统计学意义(P<0.01);同时随双顶径增加而增大,与双顶径呈高度相关性,相关系数r分别为0.922、0.914、0.916,差异有统计学意义(P<0.01)。结论建立不同孕龄和双顶径胎儿甲状腺正常参考范围,不仅有助于监测高风险胎儿甲状腺的大小,及早发现甲状腺功能异常;还可通过监测甲状腺大小来评估甲状腺肿大胎儿宫内治疗的效果。Objective To explore the correlation between different gestational age,biparietal diameter and fetal thyroid size by transabdominal two-dimensional ultrasound,and to provide the normal reference range of fetal thyroid for clinical evaluation of fetal thyroid function.Methods The diameter,circumference and area of the fetal thyroid were measured for 740 healthy pregnant women at 20~38 weeks,the 5th,50th and 95th percentile was calculated.The correlation between the fetal thyroid with gestational age and biparietal diameter was analyzed respectively.Results The reference range of the diameter,circumference and area of fetal thyroid at 20-38 weeks were obtained.We found the 5th,50th and 95th percentiles increased with the gestational age,and showed a high correlation with gestational age(r=0.909,0.904 and 0.913,respectively),which was statistically significant(P<0.01);And also increased with biparietal diameter,highly correlated with the biparietal diameter(r=0.922,0.914 and 0.916,respectively),which was statistically significant(P<0.01).Conclusion In this study,we established the reference range of fetal thyroid according to different gestational ages and biparietal diameter,which is not only helpful to monitor the size of fetal thyroid at high risk for early detection of fetal goiter dysfunction,but also can assess the effect of intrauterine therapy on goiter fetuses by monitoring fetal thyroid size.

关 键 词：胎儿甲状腺 甲状腺肿大 二维超声 产前诊断 

分 类 号：R715.5[医药卫生—妇产科学]