老年2型糖尿病与血小板、凝血及纤溶功能的相关性  

Correlation of Platelet Function,Coagulation and Fibrinolytic System Function in Elderly Patients with Type 2 Diabetes

作　　者：张琳[1] 李燕英 孟琦[1] 李灿晖[1] 沈芸[1] 毕鸿雁[1] 杨秋萍[2] 熊悦 ZHANG Lin;LI Yan-ying;MENG Qi;LI Can-hui;SHEN Yun;BI Hong-yan;YANG Qiu-ping;XIONG Yue(Dept.of General Medicine,The 1st Affiliated Hospital of Kunming Medical University,Kunming Yunnan 650032,China;Geriatrics Department,The 1st Affiliated Hospital of Kunming Medical University,Kunming Yunnan 650032,China)

机构地区：[1]昆明医科大学第一附属医院全科医学科,云南昆明650032 [2]昆明医科大学第一附属医院老年病科,云南昆明650032

出　　处：《昆明医科大学学报》2021年第11期62-67,共6页Journal of Kunming Medical University

基　　金：云南省科技厅-昆明医科大学应用基础研究联合专项基金资助项目[2018FE001(-212)];云南省医疗卫生内设研究机构项目(2017NS 019)。

摘　　要：目的探讨老年2型糖尿病患者的血小板功能、凝血功能、纤溶系统的特点。方法选取193例患者,按WHO标准诊断标准分为2型糖尿病组(DM组,97例)和对照组(NC组,96例)。收集所有患者的性别、年龄、糖尿病病程、吸烟史、SBP、DBP、BMI、FPG、2 hPG、HbA1c、FC、TC、TG、ACT、PF、D-2聚体等指标,比较以上指标的组间差异。并对PF、D-2聚体相关因素行Pearson相关性分析及多元线性回归分析。结果(1)糖尿病组BMI、D-2聚体、ACT较对照组高,组间差异有统计学意义(P<0.05);(2)Pearson相关性分析:D-2聚体值与年龄、BMI、糖尿病病程具有显著正相关性(P<0.05),与糖化血红蛋白百分比正相关性更为显著(P<0.01);PF与餐后2 h胰岛素、餐后2 h C肽具有显著负相关性(P<0.05),与空腹血糖正相关性更为显著(P<0.01);(3)多重线性回归分析:年龄和糖化血红蛋白百分比与D-2聚体存在正相关关系(P<0.05);空腹血糖与PF存在正相关关系,餐后2 h胰岛素与PF存在负相关关系(P<0.05)。结论老年2型糖尿患者存在血小板功能、凝血功能、纤容系统功能异常,高血糖、胰岛功能差可能是其主要原因。Objective To investigate the platelet function,coagulation function and fibrinolytic system in elderly patients with type 2 diabetes.Methods 193 patients were divided into type 2 diabetes group(group DM,97 cases)and control group(group NC,96 cases)according to WHO standard diagnostic criteria.The gender,age,duration of diabetes,smoking history,SBP,DBP,BMI,FPG,2 h PG,HbA1c,FC,TC,TG,ACT,PF,and aggregation polymer were collected and compared among the patients.Pearson correlation analysis and multiple linear regression analysis were performed on the related factors of PF and D-2 polymer.Results(1)The levels of BMI,D-2 polymer and ACT in the DM group were higher than those in the control group(P<0.05).(2)Pearson correlation analysis:The value of D-2 aggregate was positively correlated with age,BMI,and duration of diabetes(P<0.05),and positively correlated with the percentage of glycosylated hemoglobin(P<0.01).PF had significant negative correlation with the levels of 2 h postprandial insulin and C peptide(P<0.05),and more significant positive correlation with fasting blood glucose(P<0.01).(3)Multiple linear regression analysis:age and percentage of glycosylated hemoglobin were positively correlated with D-2 polymer(P<0.05).There was a positive correlation between fasting blood glucose and PF,and a negative correlation between insulin and PF at 2 hours after meal(P<0.05).Conclusion There are abnormal platelet function,coagulation function and fibrous function system in elderly patients with type 2 diabetes mellitus,high state of blood glucose and poor function of isolated islets may be the main reasons.

关 键 词：老年2型糖尿病 血小板功能 凝血功能 纤溶系统功能 

分 类 号：R587.1[医药卫生—内分泌] R446.11[医药卫生—内科学]