血清hs-CRP、PCT、尿β;-微球蛋白检测诊断小儿尿路感染的临床分析  

Clinical analysis of serum hs-CRP, PCT, and urine β_2-MG in diagnosis of urinary tract infection in children

作　　者：任杰[1] 范哲琦 REN Jie;FAN Zhe-qi(Clinical Laboratory,Zhengzhou First People's Hospital,Zhengzhou 450004,Henan,China)

机构地区：[1]郑州市第一人民医院检验科,河南郑州450004

出　　处：《中国校医》2021年第10期796-798,共3页Chinese Journal of School Doctor

摘　　要：目的研究血清超敏C反应蛋白(hs-CRP)、降钙素原(PCT)、尿β2-微球蛋白(尿β_2-MG)水平检测诊断小儿尿路感染的价值。方法选取我院2017年3月—2020年1月接收的72例泌尿科患儿临床资料,按随机数字表法分为尿路感染组与非尿路感染组。比较两组血清hs-CRP、PCT、尿液β_2-MG水平,并分析血清hs-CRP、PCT、尿β_2-MG水平单独及联合检测对小儿尿路感染的诊断价值。结果尿路感染组血清hs-CRP、PCT、尿β_2-MG水平分别为(26.58±3.14)mmol/L、(6.89±2.85)μg/L、(0.79±0.27)mg/L,均高于非尿路感染组的(8.34±5.21)mmol/L、(2.16±1.48)μg/L、(0.11±0.04)mg/L,差异有统计学意义(t=17.991、8.837、14.948,P均<0.001);绘制ROC曲线结果显示,血清PCT、hs-CRP、尿β_2-MG单独及联合诊断小儿尿路感染的AUC分别为:0.776、0.922、0.865、0.950,诊断效能均较理想,且以联合诊断的价值最高。结论血清hs-CRP、PCT、尿β_2-MG水平可作为临床初步诊断小儿尿路感染的诊断依据,为临床制定干预或治疗措施提供依据。Objective(PCT), and urine β2-microglobulin(urine β;-MG) in the diagnosis of urinary tract infection in children.MethodsThe clinical data of 72 cases of the urology department of our hospital were selected from March 2017 to January 2020, and according to the random number table method, they were divided into a urinary tract infection group and a non-urinary tract infection group. The levels of serum hs-CRP, PCT, and urine β;-MG were compared between the two groups, and the diagnostic values of serum hs-CRP, PCT, and urine β;-MG levels, alone and combined detection, were evaluated in urinary tract infection in children.Resultsthe levels of serum hs-CRP, PCT, and urine β;-MG in the urinary tract infection group were(26.58±3.14) mmol/L,(6.89±2.85)μg/L, and(0.79±0.27) respectively, which were higher than those in the non-urinary tract infection group:(8.34±5.21) mmol/L,(2.16±1.48) μg/L, and(0.11±0.04) mg/L respectively, and the differences were statistically significant(t = 17.991, 8.837, 14.948, P < 0.001). The results of drawing ROC curves sowed that AUCs of serum PCT, hs-CRP, and urinary β;-MG, alone and combined detection, in the diagnosis of children with urinary tract infection were 0.776, 0.922, 0.865, and 0.950 respectively. The diagnostic efficacy was satisfactory, and the value of combined diagnosis was the highest.ConclusionThe levels of serum hs-CRP, PCT, and urine β;-MG can be used as the basis for the diagnosis of urinary tract infection in children, and provide the basis for clinical intervention or treatment.

关 键 词：小儿尿路感染 超敏C反应蛋白、PCT、尿β2-微球蛋白 诊断价值 

分 类 号：R446.1[医药卫生—诊断学]