高效杀菌剂硅噻菌胺的合成工艺研究进展  

Research Progress on Synthesis of Silthiofam:a High Efficiency Bactericide

作　　者：曹运朝 韩芬芳 段凌枫 李成斌 门靖 CAO Yun-chao;HAN Fen-fang;DUAN Ling-feng;LI Cheng-bin;MEN Jing(Xi′an Wanlong Pharmaceutical Co.,Ltd.,Xi′an 710119,Shannxi;Xi′an Libang Pharmaceutical Co.,Ltd.,Xi′an 710000,Shannxi)

机构地区：[1]西安万隆制药股份有限公司,西安710119 [2]西安力邦制药有限公司,西安710000

出　　处：《有机硅材料》2021年第6期72-77,共6页Silicone Material

摘　　要：硅噻菌胺是一种三甲基硅基取代的噻吩甲酰胺类活性化合物,为高效的小麦全蚀病杀菌剂药物。依据起始原料的不同,重点介绍了以2-丁酮和氰基乙酸乙酯、3-氯-2-丁酮和丙炔酸甲酯、3-巯基-2-丁酮和3-甲氧基丙烯酸甲酯、三甲基硅基乙炔、N-烯丙基-3-(三甲基硅基)丙炔酰胺为原料的五种合成路线,对比分析了每种合成工艺的优劣势及硅噻菌胺制备过程中的杂质以及减少杂质的应对方法。Silathiofam is an active compound of trimethylsilyl substituted thiophene formamide,which is an efficient take-all-disease fungicide for wheat.According to the different starting materials,five synthetic routes with raw materials of 2-butanone and ethyl cyanoacetate,3-chloro-2-butanone and methyl propionate,3-mercapto-2-butanone and methyl 3-methoxypropionate,trimethylsilyl acetylene and N-allyl-3-(trimethylsilyl)propionamide are reviewed.The advantages and disadvantages of each synthetic process are compared and analyzed.The impurities in the preparation of silthiofam and the countermeasures to reduce the impurities are compared and analyzed.

关 键 词：硅噻菌胺 小麦全蚀病 三甲基硅基 噻吩甲酰胺 合成工艺 

分 类 号：TQ264.1[化学工程—有机化工]