MRI在帕金森叠加综合征与帕金森病的鉴别诊断及疾病进展预测中的应用  

Applicalions of MRI in the differential diagnosis and progression prediction of Parkinsonism-plus syndrome and Parkinson’s disease

作　　者：刘朝曦 张一玮 有慧[1] 冯逢(审校)[1] LIU Zhaoxi;ZHANG Yiwei;YOU Hui;FENG Feng(Department of Radiology,Peking Union Medical College Hospital,Peking Union Medical College,Chinese Academy of Medical Sciences,Beijing 100730,China)

机构地区：[1]中国医学科学院北京协和医学院北京协和医院放射科,北京100730

出　　处：《国际医学放射学杂志》2021年第6期657-661,共5页International Journal of Medical Radiology

基　　金：中国医学科学院中央级公益性科研院所基本科研业务费临床与转化医学研究基金项目(2019XK320048)。

摘　　要：帕金森叠加综合征(PPS)是一组部分临床症状与帕金森病(PD)相重叠的慢性进行性神经退行性疾病,两者症状的相似性导致了临床鉴别困难。随着神经影像技术的发展,MRI凭借其对结构、扩散、灌注及功能等多模态成像的优势在揭示PPS和PD的脑区灰质体积改变、白质纤维束完整性改变,局部脑区的铁沉积、血流灌注及功能连接等的异常改变方面提供了诸多信息。就MRI在PPS及PD鉴别诊断及疾病进展预测中的应用进展予以综述。Parkinsonism-plus syndrome(PPS)is a group of chronic progressive neurodegenerative diseases in which partial clinical symptoms overlap with Parkinson’s disease(PD).The similarity of clinical symptoms makes clinical differential diagnosis difficult.With the development of neuroimaging technology,MRI could provide a lot of information concerning abnormal changes in gray matter volume,white matter fiber bundle integrity,regional iron deposition,cerebral blood flow and functional connection in PPS and PD patients relying on its advantages in multimodal imaging in structure,diffusion,perfusion,and function.We reviewed the progress of MRI in the differential diagnosis and progression prediction of PPS and PD .

关 键 词：帕金森叠加综合征 帕金森病 磁共振成像 

分 类 号：R445.2[医药卫生—影像医学与核医学]