增材制造可降解金属医用植入物  

Additively Manufactured Biodegrabable Metal Implants

作　　者：郑玉峰[1] 夏丹丹[2] 谌雨农 刘云松[2] 徐钰倩 温鹏[3] 田耘[4] 赖毓霄 ZHENG Yufeng;XIA Dandan;SHEN Yunong;LIU Yunsong;XU Yuqian;WEN Peng;TIAN Yun;LAI Yuxiao(School of Materials Science and Engineering,Peking University,Beijing 100871,China;Department of Prosthodontics,Peking University School and Hospital of Stomatology,National Clinical Research Center for Oral Diseases,National Engineering Laboratory for Digital and Material Technology of Stomatology,Beijing Key Laboratory of Digital Stomatology,National Medical products Administration Key Laboratory for Dental Materials,Research Center of Engineering and Technology for Digital Dentistry,Ministry of Health,Beijing 100081,China;State Key Laboratory of Tribology,Department of Mechanical Engineering,Tsinghua University,Beijing 100084,China;Department of Orthopedics,Peking University Third Hospital,Beijing 100191,China;Institute of Biomedical and Health Engineering,Shenzhen Institute of Advanced Technology,Chinese Academy of Sciences,Shenzhen 518055,China)

机构地区：[1]北京大学材料科学与工程学院,北京100871 [2]北京大学口腔医(学)院修复科,国家口腔疾病临床医学研究中心,口腔数字化医疗技术和材料国家工程实验室,口腔数字医学北京市重点实验室,口腔材料国家药监局重点实验室,卫生部口腔医学计算机应用工程技术研究中心,北京100081 [3]清华大学,机械工程系,摩擦学国家重点实验室,北京100084 [4]北京大学第三医院骨科,北京100191 [5]中国科学院深圳先进技术研究院,生物医学与健康工程研究所,深圳518055

出　　处：《金属学报》2021年第11期1499-1520,共22页Acta Metallurgica Sinica

基　　金：国家重点研发计划项目No.2018YFE0104200;国家自然科学基金项目Nos.51931001、51901003、52171233及82170929;口腔材料国家药监局重点实验室开放课题项目No.PKUSS20200401;中国科学院创新交叉团队项目No.JCTD-2020-19。

摘　　要：增材制造技术由于其高精度、高自由度等特点,可赋予医用金属植入物定制化的宏观与微观结构,使植入物与患者待修复缺损部位实现更好的生物力学适配,满足临床治疗个性化方案的需求,并为医用金属植入物的制造提供新途径。可降解金属目前是医用金属的研究热点,增材制造可降解金属医用植入物是个新方向,本文重点对增材制造镁基、锌基、铁基可降解金属的工艺流程及影响因素、力学性能、降解行为、生物相容性相关结果进行分析与总结,并展望了增材制造技术在医用可降解金属植入物领域的未来发展方向。Additive manufacturing(AM)can produce complicated structures accurately and freely,giving the implant a macro and micro geometry,which makes the implant match the patient.s defect site and realize the needs for personalized clinical treatment.Thus,AM provides a new manufacturing method for biodegradable metals.Presently,biodegradable metals are the hotspot issues of metallic biomaterials research.Additively-manufactured biodegradable metals are new research field.In this paper,a comprehensive review on the AM of Mg-,Zn-,and Fe-based biodegradable metals,which focuses on their processes and influencing factors,mechanical properties,biodegradation behavior,and biocompatibility,is given.Finally,the future development trend of the AM biomedical metallic materials is explored.

关 键 词：增材制造 可降解金属 力学性能 降解行为 生物相容性 

分 类 号：R318.08[医药卫生—生物医学工程]