N端脑钠肽前体和D-二聚体在慢性阻塞性肺疾病合并肺癌中的表达及临床意义  

Value of Combined Detection of N-terminal Pro-brain Natriuretic Peptide and D-dimer in Patients with Chronic Obstructive Pulmonary Disease Complicated with Lung Cancer

作　　者：王春侠[1] 门翔[1] 郑大炜[1] 段秋立 周小果[1] 董万里[1] 李展 WANG Chunxia;MEN Xiang;ZHENG Dawei(Nanyang Central Hospital, Nanyang,473009)

机构地区：[1]河南省南阳市中心医院,473009

出　　处：《实用癌症杂志》2021年第11期1787-1790,共4页The Practical Journal of Cancer

基　　金：南阳市科技局科技攻关项目(编号:KJGG193);河南省科技攻关项目(编号:182102310184)。

摘　　要：目的探讨N端脑钠肽前体(NT-proBNP)和D-二聚体(D-dimer)在慢性阻塞性肺疾病合并肺癌中的表达及其临床意义。方法选取137例慢性阻塞性肺疾病患者作为研究对象,将77例单纯慢性阻塞性肺疾病患者作为对照组,将60例慢性阻塞性肺疾病合并肺癌患者作为观察组。对比2组患者的N端脑钠肽前体与D-二聚体水平,分析观察组不同临床特征患者的N端脑钠肽前体与D-二聚体水平,最后分析N端脑钠肽前体与D-二聚体对慢性阻塞性肺疾病合并肺癌患者的临床意义。结果观察组患者的NT-proBNP和D-dimer水平明显高于对照组(P<0.05)。通过对比60例慢性阻塞性肺疾病合并肺癌患者的不同临床特征发现,不同COPD病情严重程度、COPD分期、组织分化程度、有无远处转移患者的NT-proBNP水平对比差异显著(P<0.05),不同肺癌临床分期的患者NT-proBNP水平虽然有一定差异,但是差异并无统计学意义(P>0.05);不同肺癌临床分期、COPD分期、有无远处转移患者的D-dimer水平对比差异显著(P<0.05),不同COPD病情严重程度、组织分化程度的D-dimer水平虽然有一定差异,但是差异并无统计学意义(P>0.05)。Logistic回归分析显示,N端脑钠肽前体与D-二聚体均是发生慢性阻塞性肺疾病合并肺癌的独立影响因素。结论N端脑钠肽前体和D-二聚体在慢性阻塞性肺疾病合并肺癌患者中的表达高于单纯阻塞性肺疾病患者;而且在一定程度上可以判定慢性阻塞性肺疾病合并肺癌患者的疾病发展情况。Objective To investigate the expression and clinical significance of N-terminal pro-brain natriuretic peptide(NT-proBNP)and D-dimer(D-dimer)in chronic obstructive pulmonary disease with lung cancer.Methods 137 patients with chronic obstructive pulmonary disease were selected as the research object.77 patients with simple chronic obstructive pulmonary disease were divided into the control group and 60 patients with chronic obstructive pulmonary disease complicated with lung cancer were divided into the observation group.The levels of N-terminal pro brain natriuretic peptide and D-dimer in the 2 groups were compared,and the levels of N-terminal pro brain natriuretic peptide and D-dimer in the observation group were analyzed.Finally,the clinical significance of N-terminal pro-brain natriuretic peptide and D-dimer in patients with chronic obstructive pulmonary disease complicated with lung cancer was analyzed.Results The levels of NT proBNP and D-dimer in the observation group were significantly higher than those of the control group(P<0.05);by comparing the different clinical characteristics of 60 patients with chronic obstructive pulmonary disease complicated with lung cancer,it was found that the patients with different severity of COPD,COPD stage,degree of tissue differentiation and whether or not had distant metastasis and level of NT proBNP had significant difference(P<0.05).The level of NT proBNP in patients with different clinical stages of lung cancer had certain difference,but the difference was not statistically significant(P>0.05);the levels of D-dimer in patients with different clinical stages of lung cancer,COPD stage and distant metastasis were significantly different(P<0.05),and the levels of D-dimer in patients with different severity of COPD and tissue differentiation were significantly different(P<0.05).Logistic regression analysis showed that both N-terminal pro-brain natriuretic peptide and D-dimer were independent factors influencing the occurrence of chronic obstructive pulmonary disease with l

关 键 词：N端脑钠肽前体 D-二聚体 慢性阻塞性肺疾病合并肺癌 

分 类 号：R734.2[医药卫生—肿瘤]