青藤碱治疗大骨节病探讨  

Disscution on Sinomenine in the treatment of Kashin-Beck disease

作　　者：阮珍 寇久社 王东 郭雄[4] 唐赛清 骞童 RUAN Zhen;KOU Jiu-she;WANG Dong;GUO Xiong;TANG Sai-qing;QIAN Tong(The Second Clinical Medical College of Shaanxi University of Chinese Medicine,Xianyang,Shaanxi 712046.China)

机构地区：[1]陕西中医药大学第二临床医学院,陕西咸阳712046 [2]陕西中医药大学第二附属医院 [3]陕西中医药大学医学科研实验中心 [4]西安交通大学医学部公共卫生系环境与疾病相关基因教育部重点实验室

出　　处：《中国地方病防治》2021年第5期491-494,共4页Chinese Journal of Control of Endemic Diseases

基　　金：陕西省科技计划项目(2019JM-483);陕西省中医药管理局-临床平台项目(LCPT085);陕西中医药大学第二附属医院学科创新团队项目(2020XKTD-A03)。

摘　　要：大骨节病(Kashin-Beck Disease,KBD)是一种地方性疾病,其特征性病理变化是机体关节软骨和生长板内透明软骨细胞的坏死。青藤碱(Sinomenine,SIN)是中药青风藤的主要活性物质,具有镇痛、抗炎、免疫抑制及软骨细胞的保护等作用,广泛应用于骨关节炎、类风湿性关节炎等多种骨关节疾病的治疗,大骨节病与骨关节炎同属"痹症",两者具有相似的临床特征和骨软骨病理改变,目前尚无青藤碱用于大骨节病治疗的研究。本文探讨了青藤碱可用于大骨节病的治疗并阐述了其可能潜在的机制,旨在为大骨节病治疗的进一步研究及临床应用提供绵薄之力。Kashin-Beck disease(KBD)is an endemic disease characterized by necrosis of cartilage cells in articular cartilage and growth plates.Sinomenine(SIN)is a compound extracted from Sinomenine genus,which has analgesic,anti-inflammatory,immunosuppressive and chondrocyte protection effects.It is widely used in the treatment of osteoarthritis,rheumatoid arthritis and other arthritic diseases.Currently,there is no research on the application of SIN in the treatment of KBD.In this paper,we suggest that SIN can be used in the treatment of KBD and explain its potential mechanism,aiming to provide a modest contribution to the further research and clinical application of KBD treatment.

关 键 词：大骨节病 青藤碱 探讨 

分 类 号：R684.1[医药卫生—骨科学]