角膜接触镜的聚羧酸甜菜碱表面改性研究  

Surface Modification of Contact Lenses with Biocompatible Polymers Enables Anti⁃fouling Surface

作　　者：余洁[1] 赵海岚[1] 张岚[1] YU Jie;ZHAO Hailan;ZHANG Lan(Department of Ophthalmology,Zhejiang Provincial People's Hospital(Hospital of Hangzhou Medical College),Hangzhou 310014,China)

机构地区：[1]浙江省人民医院(杭州医学院附属人民医院)眼科,杭州310014

出　　处：《材料导报》2021年第S02期488-491,507,共5页Materials Reports

基　　金：浙江省医药卫生科技计划项目(2019PY020);浙江省哲学社会科学规划课题(19NDJC068YB)。

摘　　要：角膜接触镜由于具有方便美观、柔软不易碎、视野更宽、不上水汽等优点,使用率非常高。然而,在角膜接触镜佩戴过程中,蛋白质易沉积到镜片表面,导致炎症等多种不良反应。针对这一关键临床问题,本工作提出了利用表面引发原子转移自由基聚合(ATRP)对硅水凝胶角膜接触镜进行表面修饰,将两性离子单体羧酸甜菜碱聚合接枝到角膜接触镜表面,通过接触角测量仪、X射线光电子能谱技术(XPS)、原子力显微镜(AFM)等手段证明了接枝聚合的成功进行。聚羧酸甜菜碱(PCBMA)接枝后的角膜接触镜具有极低的粗糙度和超强的亲水性。由于PCBMA的优异的生物相容性,PCBMA接枝后的角膜接触镜能有效阻抗蛋白质的吸附和细菌的黏附。该方法证明了PCBMA表面接枝是一种有效的角膜接触镜表面改性手段。Currently,more and more people use contact lenses because of the multiple advantages including less affection by wet weather,a wider field of vision,elegant personal appearance,etc.However,protein adsorption on the surface of contact lenses can cause a series of adverse effects,such as reduced vision,inflammatory complications,and increased discomfort.In order to address this issue,carboxylic acid betaine was grafted to the surface of silicone hydrogel⁃based contact lenses via surface⁃initiated atom transfer radical polymerization.The successful surface grafting was confirmed by contact angle measurement,X⁃ray photoelectron spectroscopy(XPS),and atomic force microscopy(AFM).Due to the outstanding biocompatibility of poly(carboxylic acid betaine),the contact lenses after surface modification exhibited excellent resistance to protein adsorption and bacterial adhesion.Moreover,this method shows great potential in surface modification of contact lenses.

关 键 词：角膜接触镜 生物相容性 表面修饰 原子转移自由基聚合 抗蛋白质吸附 

分 类 号：TQ314[化学工程—高聚物工业]