pH响应型三维纳米纤维的构建及其性能研究  

Fabrication and Performance of pH⁃responsive Polymer⁃based 3D Nanofibers

作　　者：雷颖 葛冲冲 冯瑾[2] 尚娇娇 LEI Ying;GE Chongchong;FENG Jin;SHANG Jiaojiao(College of Biomass Science and Engineering,Sichuan University,Chengdu 610065,China)

机构地区：[1]四川大学轻工科学与工程学院纺织材料系,成都610065 [2]四川大学轻工科学与工程学院,成都610065

出　　处：《材料导报》2021年第S02期508-512,共5页Materials Reports

基　　金：中央高校基本科研业务费专项资金(YJ201959);四川省科技厅项目(2021YJ0290)。

摘　　要：以甲基丙烯酸二乙氨基乙酯(DEAEMA)、甲基丙烯酸甲酯(MMA)和4-丙烯酰氧基二苯甲酮(ABP)为反应单体,采用自由基聚合法制备可光引发交联的共聚物P(DEAEMA-co-MMA-co-ABP)及其纳米纤维。利用傅里叶变换红外光谱仪(FT-IR)、核磁(1H NMR)和凝胶渗透色谱分析仪(GPC)确定共聚物的化学结构和分子量;采用热失重分析仪(TGA)和差示扫描量热仪(DSC)对该共聚物的玻璃化转变温度以及热稳定性进行测试,表明主链季碳原子上空间位阻较大的MMA和刚性ABP有助于提高共聚物的玻璃化转变点和热稳定性;利用分光光度计测试共聚物在不同pH值溶液中的吸光度,证明其pH响应性能;通过光学及扫描电子显微镜(SEM)对纳米纤维形貌进行表征,并研究交联纳米纤维的pH响应性。实验结果表明,DEAEMA、MMA、ABP物质的量比为80∶10∶10的聚合物表现出敏感的pH响应性能和高效的光交联性能,且在DMF、THF体积比为1∶9,固含量浓度为40wt%的条件下,聚合物可纺制成形貌均匀的纳米纤维。交联后的三维纳米纤维在酸碱溶液中具有可逆的溶胀和收缩的性能,有望被应用于药物控释及组织载体领域。Diethyl methacrylate(DEAEMA),methyl methacrylate(MMA)and 4⁃acrylloxybenzophenone(ABP)were used as monomers to prepare a series of photo⁃initiable cross⁃linked polymer P(DEAEMA⁃co⁃MMA⁃co⁃ABP)by free radical polymerization and then the synthesized copolymer was spun to be nanofibers.Fourier transform infrared spectroscopy(FT⁃IR),nuclear magnetic field(1H NMR),gel penetration chromatography(GPC),thermogravimetric analysis(TGA)were used to test and characterize the chemical composition,structure and properties of the copolymers.The morphology of the nanofibers was characterized by optical and scanning electron microscopy(SEM),and the pH responsiveness of both synthesized copolymer and the cross⁃linked nanofibers were studied via changing the pH of solutions.The results show that the copolymer with 80∶10∶10 molar ratio of DEAEMA/MMA/ABP exhibits sensitive pH response,and the nanofibers with uniform morphology can be spun under the conditions with volume ratio of DMF/THF at 1∶9 and mass concentration of copolymer at 40wt%.Moreover,the cross⁃linked 3D nanofibrous mats have the properties of reversible swelling and contraction in acid⁃base solutions.Such nanofibrous mats can be used in the fields of controlled drug release and tissue carrier.

关 键 词：pH响应性能 pH响应聚合物 纳米纤维 药物载体 

分 类 号：O63[理学—高分子化学]