接种四价HPV疫苗患者宫颈病变特征分析  

Characteristics of cervical lesions in patients vaccinated with tetravalent HPV vaccine

作　　者：李新敏[1] 任宏 赵国红 王香枝[1] 古雅丽[1] 郭华峰[1] LI Xinmin;REN Hong;ZHAO Guohong;WANG Xiangzhi;GU Yali;GUO Huafeng(Department of Pathology,Women and Infants Hospital of Zhengzhou,Zhengzhou,Henan 450012,China;Department of Disease Control and Prevention,Women and Infants Hospital of Zhengzhou,Zhengzhou,Henan 450012,China)

机构地区：[1]郑州市妇幼保健院病理科,河南郑州450012 [2]郑州市妇幼保健院疾控科,河南郑州450012

出　　处：《中国医学工程》2021年第11期13-16,共4页China Medical Engineering

基　　金：河南省医学科技攻关计划联合共建项目(LHGJ20191135,LHGJ20191134)。

摘　　要：目的分析接种四价人乳头瘤病毒(HPV)疫苗患者宫颈病变特征。方法收集2017年11月17日至2019年6月20日在郑州市妇幼保健院进行四价HPV疫苗接种女性448例,采用回顾性分析方法,对接种人群随访宫颈HPV检查史和宫颈手术史,不同组别间对比分析。结果 448例20~45岁接种患者中位年龄(33±6.1)岁,其中30~39岁患者占接种人群的一半,为49.8%(223/448),随访成功率为97.5%(437/448)。曾进行过HPV检查占63.2%(276/437),HPV阳性者占14.9%(41/276)。41例HPV阳性病史患者接种时,20例为阴性,21例为阳性,且3例患者仍为HPV16亚型阳性。16例患者有宫颈活检病史,其中3例患者曾行宫颈锥切术,1例行宫颈利普刀术。同样,30~39岁占HPV阳性患者的大部分,为68.3%(28/41)。结论宫颈曾有HPV检查史和/或治疗史的患者占接种人群大部分。【Objective】 To analyze the characterisitics of cervical lesions in patients vaccinated with tetravalent HPV vaccine.【Methods】 The information of 448 patients vaccinated with tetravalent HPV vaccine were extracted from Department of Disease Control and Prevention,Women and Infants Hospital of Zhengzhou from November 17,2017 to June 20,2019.Retrospective analysis was used to analyze the history of cervical HPV examination and cervical surgery among the vaccinated population.【Results】 The median age of 448 vaccinated patients was 33±6.1 years(20-45 years).Half of the vaccinated population,49.8%(223/448),were 30-39 years old.The follow-up success rate was 97.5%(437/448).63.2%(276/437) patients had been examined for HPV.There were 14.9%(41/276) patients with HPV positive.Among 41 patients with HPV positive history,20 patients were negative,21 patients were positive,and 3 patients with HPV 16 subtype positive.Sixteen patients had a history of cervical biopsy,of which 3 had undergone cervical conization and 1 had undergone cervical LEEP knife.Similarly,68.3%(28/41) of HPV-positive patients were aged 30-39.【Conclusion】 Patients with a history of HPV testing and/or treatment in the cervix accounted for the majority of the vaccinated population.

关 键 词：人乳头瘤病毒 疫苗 子宫颈 宫颈癌 

分 类 号：R186[医药卫生—流行病学]