急性一氧化碳中毒心肌损害与迟发脑病的相关性研究  

Correlation between acute carbon monoxide poisoning-induced myocardial damage and delayed encephalopathy

作　　者：姚斐 萧欣 沃金善[1,2] Yao Fei;Xiao Xin;Wo Jinshan(Qingdao University,Qingdao 266000,China)

机构地区：[1]青岛大学,山东省青岛266000 [2]海军第九七一医院军事医学与特种医学科

出　　处：《中华航海医学与高气压医学杂志》2021年第5期599-601,606,共4页Chinese Journal of Nautical Medicine and Hyperbaric Medicine

摘　　要：目的研究急性一氧化碳中毒患者心肌损害与迟发脑病的关系。方法回顾性分析海军第九七一医院2016年11月至2020年11月收治的205例急性一氧化碳中毒患者的病例资料,根据是否发生迟发脑病将患者分为脑病组(n=110)和非脑病组(n=95)。对比2组患者入院24 h内心肌损害相关指标及心电图检测结果。结果脑病组患者的血清肌酸激酶、肌酸激酶同工酶、血清肌钙蛋白Ⅰ、肌红蛋白及乳酸脱氢酶水平高于非脑病组患者,差异有统计学意义(P<0.01);脑病组患者心电图ST-T改变、房室传导阻滞发生率高于非脑病组患者,差异有统计学意义(P<0.05)。结论急性一氧化碳中毒患者心肌损害指标及早期心电图表现与迟发脑病关系密切。Objective To study the correlation between myocardial damage and delayed encephalopathy in patients with acute carbon monoxide poisoning(ACOP).Methods The clinical data of 205 patients with ACOP treated in No.971 Hospital of the PLA Navy from November 2016 to November 2020 were retrospectively analyzed.The patients were divided into encephalopathy group(n=110)and non-encephalopathy group(n=95)based on whether they had delayed encephalopathy.Myocardial damage-related indicators and the results of electrocardiogram(ECG)analysis within 24 hours after admission were compared between the two groups.Results The levels of serum creatine kinase(CK),creatine kinase isoenzyme(CK-MB),cardiac troponin I(cTnI),myoglobin(Mb),and lactate dehydrogenase(LDH)in the encephalopathy group were higher than those in the non-encephalopathy group,with statistically significant differences(P<0.01).The incidences of ECG ST-T changes and atrioventricular block in the encephalopathy group were higher than those in the non-encephalopathy group,with statistically significant differences(P<0.05).Conclusion Myocardial damage-related indicators and the early ECG results in patients with ACOP are closely correlated with the incidence of delayed encephalopathy.

关 键 词：一氧化碳中毒 心肌损害 心电图 迟发脑病 

分 类 号：R595.1[医药卫生—内科学] R747.9[医药卫生—临床医学]