阿伦磷酸钠联合高压氧治疗对老年骨质疏松症患者的临床疗效及血清骨代谢的影响  

Clinical efficacy of alendronate combined with hyperbaric oxygen on elderly patients with osteoporosis and its effect on serum bone metabolism

作　　者：董宏财 王臣[1] 王广欣[1] 范峥 Dong Hongcai;Wang Chen;Wang Guangxin;Fan Zheng(Department of Orthopedics,The Fourth People’s Hospital of Shenyang,Shenyang 110031,China)

机构地区：[1]沈阳市第四人民医院骨科,沈阳110031

出　　处：《中华航海医学与高气压医学杂志》2021年第5期634-637,共4页Chinese Journal of Nautical Medicine and Hyperbaric Medicine

摘　　要：目的探究阿伦磷酸钠联合高压氧治疗对老年骨质疏松症(OP)患者的疗效及血清骨代谢的影响。方法选择2017年1月至2019年12月于沈阳市第四人民医院骨科收治的老年骨质疏松患者80例,采用随机数字表法将患者分为对照组及观察组,每组40例。对照组给予阿伦磷酸钠治疗,观察组在阿伦磷酸钠治疗的同时给予高压氧治疗,均治疗6个月。分别于治疗前后采集患者空腹静脉血,电化学发光免疫分析法检测2组患者血清N-端骨钙素(N-MID)、骨特异性碱性磷酸酶(BAP)、总I型胶原氨基端延长肽(PINP)、I型胶原羧基端肽(CTX)水平;观察2组患者治疗前后疼痛数字评分(NRS)及治疗后疗效。结果观察组患者治疗后总有效率(85.00%)明显高于对照组(65.00%);治疗后观察组患者NRS评分明显低于对照组;血清N-MID、BAP、PINP、CTX水平明显低于对照组,差异均有统计学意义(P<0.05)。结论阿伦磷酸钠联合高压氧治疗可降低老年OP患者血清N-MID、BAP、PINP、CTX水平,明显缓解患者疼痛,疗效较好,可在临床推广应用。Objective To investigate the clinical efficacy of alendronate combined with hyperbaric oxygen on elderly patients with osteoporosis(OP)and its effect on serum bone metabolism.Methods A total of 80 elderly patients with OP admitted to the Department of Orthopedics of the Fourth People’s Hospital of Shenyang from January 2017 to December 2019 were selected and divided into control group(n=40)and observation group(n=40)by the random number table method.The control group received alendronate,while the observation group received alendronate combined with hyperbaric oxygen treatment.Both groups received six months of treatment.Fasting venous blood was collected before and after treatment,and serum levels of N-terminal osteocalcin(N-MID),bone-specific alkaline phosphatase(BAP),N-terminal propeptide of type I procollagen(PINP),and carboxy-terminal peptide of type I collagen(CTX)in the two groups were measured by electrochemiluminescence immunoassay(ECLI).The scores of numeric rating scale(NRS)for pain assessment were collected before and after treatment;and the clinical efficacies of the two groups after treatment were observed.Results The total effective rate of the observation group(85.00%)was significantly higher than that of the control group(65.00%);after treatment,the NRS score of the observation group was significantly lower than that of the control group;the levels of serum N-MID,BAP,PINP,and CTX in the observation group were significantly lower than those in the control group;all the differences were statistically significant(P<0.05).Conclusion Alendronate combined with hyperbaric oxygen can reduce the levels of serum N-MID,BAP,PINP,and CTX in elderly patients with OP and relieve their pain significantly with good clinical efficacy,which can be widely used in clinical practice.

关 键 词：高压氧 阿伦磷酸钠 骨质疏松症 疗效 骨代谢 

分 类 号：R580[医药卫生—内分泌]