单纯超滤与连续性静脉-血液滤过治疗肾病综合征患者难治性水肿的效果比较  

Simple ultrafiltration vs continuous venous-hemofiltration in the treatment of refractory edema in nephrotic syndrome patients

作　　者：谢林 Xie Lin(Department of Nephrology,the First People’s Hospital of Pingyuan County,Dezhou 253100,China)

机构地区：[1]平原县第一人民医院肾内科,德州市253100

出　　处：《国际移植与血液净化杂志》2021年第5期5-7,共3页International Journal of Transplantation and Hemopurification

摘　　要：目的比较单纯超滤与连续性静脉-血液滤过治疗肾病综合征患者难治性水肿的效果及安全性。方法选取本院收治的72例患者,按照数字表法随机分组,试验组、对照组各36例。试验组予以连续性静脉-血液滤过,对照组予以单纯超滤治疗。比较两组患者水肿、生化指标改善情况及平均动脉压的变化。结果试验组与对照组治疗有效率分别为94.44%和80.55%,试验组治疗有效率明显高于对照组(χ^(2)=5.257,P<0.05)。治疗后,试验组尿蛋白水平低于对照组[分别为(2.32±0.11)g/24 h和(3.32±0.17)g/24 h,t=29.632,P<0.05],试验组平均动脉压高于对照组[分别为(94.45±3.54)mmHg和(87.12±1.05)mmHg,t=11.911,P<0.05]。结论连续性静脉-血液滤过能有效改善肾病综合征患者尿蛋白等生化指标,减轻机体水肿,较单纯超滤治疗效果更优,且治疗中患者血压较为稳定,安全性较高。Objective To compare the effect of simple ultrafiltration vs continuous venous-hemofiltration in refractory edema and blood flow stability in nephrotic syndrome patients.Methods A total of 72 patients were divided into two groups according to the random number table method.The experimental group(n=36)was treated with continuous venous-hemofiltration and the control group(n=36)was treated with simple ultrafiltration interventions.The treatment effects,biochemical indexes and average arteries pressure were observed.Results The treatment effective rates of the experimental group and the control group were 94.44%and 80.55%,respectively.The treatment efficiency of the experimental group was significantly higher than that of the control group(χ^(2)=5.257,P<0.05).After the treatment,the urine protein of the experimental group was lower than that of the control group((2.32±0.11)g/24 h vs(3.32±0.17)g/24 h,t=29.632,P<0.05).After the treatment,the average arterial pressure of the experimental group was higher than that of the control group((94.45±3.54)mmHg vs(87.12±1.05)mmHg,t=11.911,P<0.05).Conclusion Comparing with simple ultrafiltration,continuous venous-hemofiltration was more effective in patients with refractory edema and nephrotic syndrome.It could effectively improve patient’s urinary protein and other biochemical indicators,reduce body edema,and the blood pressure was relatively stable during the treatment,which was safer.

关 键 词：单纯超滤 连续性静脉-血液滤过 肾病综合征 水肿 血流稳定性 

分 类 号：R692[医药卫生—泌尿科学]