儿童严重创伤性脑损伤的目标体温管理  

Targeted temperature management of severe traumatic brain injury in children

作　　者：颜景礼 许巍[1] Yan Jingli;Xu Wei(National Children′s Regional Medical Center(Northeast),Pediatric Intensive Care Unit,Shengjing Hospital of China Medical University,Shenyang 110004,China)

机构地区：[1]国家儿童区域医疗中心(东北)中国医科大学附属盛京医院小儿重症监护病房,沈阳110004

出　　处：《中国小儿急救医学》2021年第10期850-854,共5页Chinese Pediatric Emergency Medicine

基　　金：国家自然科学基金(81771621);辽宁省重点研发指导计划(2019JH8/10300023);中国医科大学附属盛京医院345人才工程计划。

摘　　要：创伤性脑损伤(TBI)是儿童死亡和残疾的主要原因之一。目标体温管理(TTM)可减少TBI患者的不良预后,许多研究致力于建立TBI患者体温管理规范。包括治疗性低温在内的TTM已被公认为神经保护治疗的候选方法之一。然而,低温治疗对严重TBI患者的疗效尚不清楚。本文将回顾对低温潜在影响的研究,讨论PICU中治疗性低温可能的神经保护机制,探讨TTM在小儿重型颅脑损伤中的作用。Traumatic brain injury(TBI)is one of leading causes of death and disability in children.Targeted temperature management(TTM)may reduce unfavorable outcomes of TBI patients,and many studies have made much effort for developing a norm in managing temperature in TBI patients.TTM,including therapeutic hypothermia,has been recognized as one of candidate methods of neuroprotective treatment.However,the efficacy of hypothermia for patients with severe TBI is not clear.In this article,we will review studies on the potential effects of hypothermia,discuss the possible pathophysiology of neuroprotection with therapeutic hypothermia in PICU,and explore the role of TTM in pediatric severe TBI.

关 键 词：创伤性脑损伤 目标体温管理 治疗性低温 儿童 

分 类 号：R726.5[医药卫生—儿科]