古方治疗胃脘痛用药规律研究  

Study on Administration Rules of Ancient Prescriptions for Epigastric Pain

作　　者：辛奕君 黄超原 赵志敏 罗虎 刘凤斌[2] XIN Yijun;HUANG Chaoyuan;ZHAO Zhimin;LUO Hu;LIU Fengbin

机构地区：[1]广州中医药大学第一临床医学院,广东广州510006 [2]广州中医药大学第一附属医院,广东广州510405

出　　处：《新中医》2021年第21期55-58,共4页New Chinese Medicine

基　　金：广州中医药大学2019年省级大学生创新创业训练计划项目(S201910572056)。

摘　　要：目的:基于大数据挖掘古方治疗胃脘痛的用药规律,为其现代临床应用及新药开发提供方向和依据。方法:收集《中华医典》中方书类、综合医书类、临证各科类书籍治疗胃脘痛的所有古方,应用中医传承辅助平台(V2.5)进行描述性统计、关联规则分析、层次聚类分析治疗胃脘痛古方的核心用药及组方规律。结果:共纳入治疗胃脘痛古方226个,涉及中药141味。药性主要为温性药,其次为平性药、寒性药;药类多为补虚药、理气药,其次为化痰祛湿药、温里药、活血化瘀药、利水渗湿药等;药味主要为辛味,其次为苦味、甘味;主要归脾、胃经;常用药物有甘草、陈皮、干姜、半夏、枳实、砂仁等;提取22个核心组合和16组用药规律,并演化得到10首治疗胃脘痛的新处方。结论:古方治疗胃脘痛与今人多疏肝解郁、清热祛湿、健脾益气的方法不同,古方更注重温脾、运脾以和胃。Objective:Based on big data mining,the administration rules of ancient prescriptions for epigastric pain were studied to provide directions and references for its modern clinical application and new drug development.Methods:All ancient prescriptions for epigastric pain in books of Chinese medicine prescriptions,comprehensive medicine and various clinical disciplines in Chinese Medical Classic were collected,and descriptive statistics,association rules analysis,and hierarchical cluster analysis were performed on the traditional Chinese medicine inheritance support system(V2.5)for the study of the core administration and prescription rules of ancient prescriptions for epigastric pain.Results:A total of226 ancient prescriptions for epigastric pain were included,involving 141 kinds of Chinese herbs;Chinese medicine with warm nature accounts for the most,followed by neutral medicine and cold medicine;deficiency-supplementing medicine and qi-regulating medicine take the majority,followed by phlegm-dampness-resolving medicine,interior-warming medicine,blood-activating and stasis-resolving medicine,and dampness-draining diuretic medicine;the flavor of medicine is mainly pungency,followed by bitterness and sweetness;the main meridian entries of medicine are the spleen meridian and the stomach meridian;commonly used medicines are Radix et Rhizoma Glycyrrhizae,Pericarpium Citri Reticulatae,Rhizoma Zingiberis,Rhizoma Pinelliae,Fructus Aurantii Immaturus,Fructus Amomi and so on;22 core combinations and 16 groups of administration rules were extracted,and 10 new prescriptions for epigastric pain were obtained.Conclusion:Different from the methods of soothing liver and resolving constraint,clearing heat and dispelling dampness,and fortifying spleen and replenishing qi for epigastric pain nowadays,ancient prescriptions pay more attention to warming and activating the spleen so as to harmonize the stomach.

关 键 词：胃脘痛 古方 数据挖掘 中医传承辅助平台 用药规律 

分 类 号：R256.33[医药卫生—中医内科学]