ClassⅡTCP转录因子的主要功能和分子调控机制  

The molecular function and regulation of ClassⅡTCP transcription factors

作　　者：兰婧秋 秦跟基[1,2] LAN JingQiu;QIN GenJi(State Key Laboratory of Protein and Plant Gene Research,School of Life Sciences,Peking University,Beijing 100871,China;School of Advanced Agricultural Sciences,Peking University,Beijing 100871,China)

机构地区：[1]北京大学生命科学学院,蛋白质与植物基因研究国家重点实验室,北京100871 [2]北京大学现代农学院,北京100871

出　　处：《中国科学：生命科学》2021年第11期1542-1557,共16页Scientia Sinica(Vitae)

基　　金：国家杰出青年科学基金(批准号:31725005);国家自然科学基金创新研究群体项目(批准号:31621001)资助。

摘　　要：TCP家族作为一类植物特有的转录因子,广泛参与各类群植物多个阶段的生长发育调控.其中ClassⅡTCP转录因子亚家族在植物的叶片发育、侧枝形成及花发育中发挥核心调控功能.TCP转录因子的活性在转录和转录后水平上均受到复杂而严密的调控.同时,TCP转录因子可通过直接结合基因启动子和增强子,或改变染色质结构等多种方式精细调控下游基因在特定发育时期的表达.本文重点阐述了ClassⅡTCP转录因子亚家族的功能、其上游调控因子及其调控下游基因的分子机制的最新进展,以期理解TCP转录因子在整合内外因素精细调控植物可塑性发育中的重要作用.TCP transcription factors are a class of plant-specific transcription factors.They extensively participate in developmental processes in multiple stages of various plant species.Among them,ClassⅡTCP subfamily plays pivotal roles in control of leaf development,shoot branch formation and flower organ development.The activity of ClassⅡTCP is tightly regulated at both transcriptional and post-transcriptional levels.They regulate the expression of downstream genes by directly binding to promoters,enhancers,and modifying chromatin structure.These mechanisms make TCP elegantly regulate plant development at specific stages during plant development.This review mainly summarized recent progress with regard to the molecular functions and regulation networks of ClassⅡTCPs,and we try to provide the recent understanding of TCP function in integrating the environmental conditions and internal signals to control plant developmental plasticity.

关 键 词：TCP转录因子 microRNA319 转录抑制因子 植物可塑性发育 

分 类 号：Q943.2[生物学—植物学]