桥本甲状腺炎西药治疗进展  

Progress of Western Medicine in Treatment of Hashimoto Thyroiditis

作　　者：王迪[1] 梁伟娟 许雷鸣 马丹[1] 郝丛莉 侯世佳 肖艳[1] WANG Di;LIANG Weijuan;XU Leiming;MA Dan;HAO Congli;HOU Shijia;XIAO Yan(Department of Endocrinology,Urumqi Hospital of Traditional Chinese Medicine Affiliated to Xinjiang Medical University,Urumqi 830000,China)

机构地区：[1]新疆医科大学附属乌鲁木齐市中医医院内分泌科,乌鲁木齐830000

出　　处：《医学综述》2021年第22期4501-4505,共5页Medical Recapitulate

摘　　要：桥本甲状腺炎(HT)是由免疫系统产生攻击甲状腺的抗体引起,治疗目标是调节机体免疫、减轻炎症反应、提高甲状腺功能等。目前HT治疗仍以西药为主,常用西药包括抗甲状腺药物(甲巯咪唑)、甲状腺激素药物(左甲状腺素钠)、免疫制剂(泼尼松、环磷酰胺)等,其中抗甲状腺药物、甲状腺激素药物具有改善甲状腺功能的作用,应用广泛。但随着HT发病机制及治疗的深入研究,发现糖皮质激素(地塞米松)、硒类药物(硒酵母)治疗HT也取得一定疗效。因此,明确HT西药治疗情况,可为优化HT治疗方案提供参考。Hashimoto thyroiditis(HT)is caused by antibodies produced by the immune system to attack the thyroid gland,and the therapeutic aim is to regulate the immunity of the body,reduce the inflammatory response and improve the thyroid function.At present,HT treatment is still dominated by western medicine,and the common western medicines include anti-thyroid drugs(methimazole),thyroid hormone drugs(levothyroxine sodium),immune preparations(prednisone,cyclophosphamide etc.),of which anti-thyroid drugs and thyroid hormone drugs have the function of improving thyroid gland and are widely used.However,with the further study of the pathogenesis and treatment of HT,it is found that glucocorticoids(dexamethasone)and selenium drugs(selenium yeast)have also achieved certain therapeutic effect in the treatment of HT.Therefore,clarifying the western medicine treatment of HT can provide references for the optimization of HT treatment plan.

关 键 词：桥本甲状腺炎 甲巯咪唑 左甲状腺素钠 泼尼松 环磷酰胺 地塞米松 硒酵母 

分 类 号：R581.4[医药卫生—内分泌]