长链非编码RNA TUG1在血管相关疾病中的研究进展  

Research Progress of Long Non-coding RNA TUG1 in Vascular Associated Diseases

作　　者：王月霞 马媛 底煜[1] WANG Yuexia;MA Yuan;DI Yu(Department of Ophthalmology,Shengjing Hospital Affiliated to China Medical University,Shenyang 110000,China)

机构地区：[1]中国医科大学附属盛京医院眼科,沈阳110000

出　　处：《医学综述》2021年第21期4171-4176,共6页Medical Recapitulate

基　　金：国家自然科学基金(81600747);辽宁省教育厅科学研究经费项目(QNZR2020010)。

摘　　要：长链非编码RNA(lncRNA)牛磺酸上调基因1(TUG1)是最早鉴定出的与人类疾病相关的lncRNA之一,lncRNA TUG1广泛参与各种疾病的病理生理过程。病理性新生血管是多种疾病(卵巢癌、肺癌、心肺血管重构、动脉粥样硬化、早产儿视网膜病变、糖尿病视网膜病变等)共有的病理改变,而lncRNA TUG1可通过作用于细胞增殖、凋亡、迁移以及炎症等控制疾病的病理性血管改变。因此,深入研究lncRNA TUG1在不同类型血管疾病中的作用有助于血管相关疾病发病机制的研究及其在临床疾病治疗中的应用。Long non-coding RNA(LncRNA)taurine upregulated gene 1(TUG1)is one of the earliest identified lncRNAs associated with human diseases.lncRNA TUG1 is extensively involved in various pathophysiological processes.Pathological neovascularization is a common pathological change in a variety of diseases(ovarian cancer,lung cancer,cardiopulmonary vascular remodeling,atherosclerosis,retinopathy of prematurity,diabetic retinopathy,etc.).lncRNA TUG1 controls the pathological vascular changes of the diseases by acting on cell proliferation,apoptosis,migration and inflammation,etc.Therefore,further study of the role of lncRNA TUG1 in different types of vascular diseases can help to the pathogenesis research and its application in the clinical treatment.

关 键 词：血管疾病 长链非编码RNA 牛磺酸上调基因1 病理性新生血管 

分 类 号：R543[医药卫生—心血管疾病]