布托啡诺与舒芬太尼在经尿道输尿管镜取石术中实施静脉麻醉的对比性研究  

The comparison of butorphanol and sufentanil in intravenous anesthesia for transurethral ureteroscopic lithotripsy

作　　者：李奕男 孙文泽 孙伟 赵子良[1] LI Yinan;SUN Wenze;SUN Wei;ZHAO Ziliang(Department of Anesthesiology,The First Affiliated Hospital of Guangzhou Medcial University,Guangzhou 510220;Department of Anesthesiology,Xingtai Women and Children Hospital,Xingtai 054000;Department of Ophtalmology,Guangdong Women and Children Hospital,Guangzhou 511400,China)

机构地区：[1]广州医科大学第一附属医院麻醉科,广东广州510220 [2]邢台市妇幼保健院麻醉科,河北邢台054000 [3]广东省妇女儿童医院眼科,广东广州511400

出　　处：《麻醉安全与质控》2021年第6期324-328,共5页Perioperative Safety and Quality Assurance

基　　金：广东省中医药科研项目(20191039)。

摘　　要：目的研究丙泊酚复合布托啡诺实施静脉麻醉的可行性,与舒芬太尼相比较的优缺点。方法选取我院2018-01/2019-08期间拟行静脉麻醉的手术患者200例为研究对象,随机分为布托啡诺组(B组,n=100)和舒芬太尼组(S组,n=100)。B组采用丙泊酚复合布托啡诺实施静脉麻醉,S组采用丙泊酚复合舒芬太尼实施静脉麻醉,对比2组麻醉效果、达到离室标准(Aldrete评分≥9分)的时间和麻醉相关不良反应。结果B组和S组麻醉优良率和术中BIS值异常增高情况比较,差异均无统计学意义(P>0.05),离室时间B组略长于S组(P<0.05),离室时2组患者BIS值比较,差异无统计学意义(P>0.05),B组嗜睡发生率高于S组(P<0.05),B组术中低血压和术中胃反流发生率低于S组(P<0.05),2组呼吸抑制及术后烦躁发生率比较,差异无统计学意义(P>0.05),术后恶心呕吐发生率B组低于S组(P<0.05)。结论丙泊酚复合布托啡诺实施静脉麻醉效果满意,术中低血压发生率明显降低;减少术中胃反流,降低误吸风险;术后恶心呕吐发生率降低,值得在临床静脉麻醉中推广应用。Objective To investigate the feasibility of propofol combined with butorphanol in intravenous anesthesia,and its advantages and disadvantages in comparison with sufentanil.Methods A total of 200 patients receiving intravenous anesthesia were randomly divided into butorphanol group(group B,n=100)and sufentanil group(group S,n=100).Patients in group B were given propofol combined with butorphanol through intravenous anesthesia,and patients in group S were given propofol combined with sufentanil through intravenous anesthesia.The classification of anesthetic effect,time to reach aldrete recovery score(Aldrete score≥9)and anaesthesia-related adverse reactions were compared between the two groups.Results There was no statistically significant difference in the excellent rate of anesthesia and the increasing of BIS value during the operation in two groups(P>0.05).The time of anesthesia resuscitation of group B was longer than that group S(P<0.05).There was no statistically significant difference comparing the BIS value of the two group when patients leaved the room(P>0.05).The incidence of drowsiness in group B was higher than that of group S(P<0.05).The incidence of intraoperative hypotension and intraoperative gastric reflux of group B was lower than that group S(P<0.05).There was no statistically significant difference in the incidence of respiratory depression and postoperative irritability(P>0.05).The occurrence of postoperative nausea and vomiting was lower in group B than those of group S(P<0.05).Conclusion The effect of propofol combined with butorphanol conducted in intravenous anesthesia was satisfied,with the reduction of the incidence of moderate hypotension,stable bloodstream dynamics,the obvious reduction of gastroesophageal reflux,and the lower risk of aspiration.The incidence of postoperative nausea and vomiting is reduced.Hence,this method is worth of applying in clinical intravenous anesthesia.

关 键 词：布托啡诺 静脉麻醉 舒芬太尼 

分 类 号：R614[医药卫生—麻醉学]