女性关键时期端粒-端粒酶系统的影响因素研究进展  

Research progress on influencing factors of female telomere-telomerase system in critical period

作　　者：张丽欣 王琪 于爽[1] 王艳艳[1] 黄莉莉[1] ZHANG Lixin;WANG Qi;YU Shuang;WANG Yanyan;HUANG Lili(Heilongjiang University of Chinese Medicine,Harbin 150040,Heilongjiang,China)

机构地区：[1]黑龙江中医药大学药学院,黑龙江哈尔滨150040

出　　处：《中国临床药理学与治疗学》2021年第11期1328-1334,共7页Chinese Journal of Clinical Pharmacology and Therapeutics

基　　金：黑龙江省自然科学基金(LH2019H106);黑龙江省普通高等学校骨干教师创新能力资助计划(1254G054);黑龙江中医药大学校科研基金资助(2012bs01);教育部重点实验室-北药基础与应用研究开放课题基金资助。

摘　　要：端粒-端粒酶系统作为衰老的生物标志物,对于维护女性健康具有重要影响。女性青春期、妊娠期和围绝经期的端粒-端粒酶系统的脆弱性增加,不仅影响自身,甚至还会影响后代的健康成长。为此,本文从雌激素水平,膳食、应激、运动、胰岛素抵抗和睡眠这几个主要方面,综述其在青春期、妊娠期、围绝经期对端粒-端粒酶系统的影响,为延缓女性衰老的介入时间和干预措施提供参考。The telomere/telomerase system,as a biological marker of aging,plays an important role in maintaining woman's health.The vulnerability of telomere-telomerase system is heightened in female during puberty,pregnancy and perimenopause period,which not only affect themselves,but also affect the healthy growth of offspring.Therefore,the purpose of this article is to provide basis for intervention time and method for delaying women aging due to the effects of estrogen levels,dietary,stress,movement,insulin resistance and sleep on the telomere/telomerase system during puberty,pregnancy and perimenopausal period.

关 键 词：青春期 妊娠期 围绝经期 端粒 端粒酶 衰老 

分 类 号：R339.3[医药卫生—人体生理学] R339.38[医药卫生—基础医学]