参麦注射液联合三七粉治疗肝硬化食管胃静脉曲张出血疗效及对凝血和免疫功能的影响  

Efficacy of Shenmai injection combined with Panax notoginseng powder on hemorrhage from esophageal and gastric varices of liver cirrhosis and its effect on blood coagulation and immune function

作　　者：刘晓东[1] 郭晓会[1] 任海霞[1] 刘利叶 王建华[1] 常晓 韩莉萍 LIU Xiaodong;GUO Xiaohui;REN Haixia;LIU Liye;WANG Jianhua;CHANG Xiao;HAN Liping(Affiliated Hospital of Hebei University of Engineering, Handan 056000, Hebei, China;Handan Children’s Hospital, Handan 056000, Hebei, China)

机构地区：[1]河北工程大学附属医院,河北邯郸056000 [2]邯郸市儿童医院,河北邯郸056000

出　　处：《现代中西医结合杂志》2021年第33期3688-3691,3730,共5页Modern Journal of Integrated Traditional Chinese and Western Medicine

基　　金：河北省邯郸市科学技术研究与发展计划项目(1223108086-10)。

摘　　要：目的观察参麦注射液联合三七粉治疗肝硬化食管胃静脉曲张出血患者的疗效及对凝血指标和T细胞免疫功能的影响。方法选择2019年6月—2020年6月河北工程大学附属医院收治的64例肝硬化食管胃静脉曲张出血患者,按照随机数字表法将患者分为2组,对照组32例给予常规西医治疗,实验组32例在对照组处理基础上给予参麦注射液静滴及三七粉口服。检测2组患者入院时、治疗72 h后凝血指标[凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、纤维蛋白原(FIB)]和免疫指标(CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)),比较2组患者治疗72 h后临床治疗效果,统计2组患者治疗期间死亡情况、并发症及药物相关不良反应发生情况。结果治疗72 h后,2组PT、APTT均较入院时明显缩短(P均<0.05),FIB及CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)均较入院时明显增高(P均<0.05);实验组PT、APTT均明显短于对照组(P均<0.05),CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)均明显高于对照组(P均<0.05),2组FIB比较差异无统计学意义(P>0.05)。实验组治疗总有效率为96.9%(31/32),显著高于对照组的71.9%(23/32),差异有统计学意义(P<0.05)。2组均无患者死亡,住院期间均未发生并发症及药物相关不良反应。结论常规西医治疗基础上给予参麦注射液和三七粉治疗可显著改善肝硬化食管胃静脉曲张出血患者凝血及免疫功能,止血效果更好且安全。Objective It is to observe the efficacy of Shenmai injection combined with Panax notoginseng powder in the treatment of patients with liver cirrhosis,esophagus and gastric varices bleeding,and its effect on coagulation indexes and T cell immune function.Methods Sixty-four patients with liver cirrhosis,esophagus and gastric varices hemorrhage admitted from June 2019 to June 2020 in the Affiliated Hospital of Hebei University of Engineering were selected and were divided into 2 groups according to the random number table method,32 patients in the control group were treated with conventional western medicine,32 cases in the experimental group were given Shenmai injection intravenously and notoginseng powder orally on the basis of the treatment in the control group.The coagulation indexes[prothrombin time(PT),activated partial thromboplastin time(APTT),fibrinogen(FIB)]and immune indexes(CD3^(+),CD4^(+),CD4^(+)/CD8^(+))of the patients were detected at admission and 72 hours after treatment in the two groups,the clinical treatment effects after 72 hours of treatment were compared between the two groups,and the deaths,occurrence of complications and drug-related adverse reactions of the patients in the two groups were counted during the treatment.Results After 72 hours of treatment,the PT and APTT of the two groups were significantly shorter than those on admission(all P<0.05),and the levels of FIB,CD3^(+),CD4^(+),CD4^(+)/CD8^(+) were all significantly higher than those on admission(all P<0.05);the PT and APTT of the experimental group were significantly shorter than those of the control group(all P<0.05),and the levels of CD3^(+),CD4^(+),CD4^(+)/CD8^(+)were significantly higher than those of the control group(all P<0.05),there was no significant difference in FIB between the two groups(P>0.05).The total effective rate of treatment in the experimental group was 96.9%(31/32),which was significantly higher than 71.9%(23/32)in the control group,and the difference was statistically significant(P<0.05).There were no deaths i

关 键 词：参麦注射液 三七粉 肝硬化 急性上消化道出血 

分 类 号：R657.31[医药卫生—外科学]