炎症因子及其相关信号通路在脊髓损伤调控机制中的研究进展  

Research progress of inflammatory factors and their related signaling pathways in the regulation of spinal cord injury

作　　者：宋洁菲 周雨昕 张宇 吴承杰 马勇[1,2] 郭杨[1,2] SONG Jiefei;ZHOU Yuxin;ZHANG Yu;WU Chengjie;MA Yong;GUO Yang(The First Medical College,Nanjing University of Chinese Medicine,Jiangsu Province,Nanjing,210023,China;New Technology Laboratory of Bone Injury Repair and Reconstruction,Nanjing University of Chinese Medicine,Jiangsu Province,Nanjing,210023,China)

机构地区：[1]南京中医药大学第一临床医学院,江苏南京210023 [2]南京中医药大学骨伤修复与重建新技术实验室,江苏南京210023

出　　处：《中国医药导报》2021年第32期38-41,共4页China Medical Herald

基　　金：国家自然科学基金青年基金项目(81704100);南京中医药大学自然科学基金青年项目(NZY81704100);南京中医药大学大学生创新创业训练计划项目(202010315 YC001)。

摘　　要：脊髓损伤(SCI)是一种严重的中枢神经系统损伤性疾病,继发性损伤是SCI预后不良的重要原因,其中炎症反应是主要的继发性损伤之一。大量文献显示,炎症因子及其相关信号通路如核因子(NF)-κB信号通路、JAK/STAT信号通路、MAPK/ERK信号通路等共同调控SCI后炎症反应,在SCI发生发展的过程中具有关键的作用。本综述根据炎症因子作用的不同将其分为促炎、抑炎因子,并结合相关信号通路,重点介绍促炎因子白细胞介素6(IL-6)、肿瘤坏死因子α等和抑炎因子IL-4、IL-10等在SCI中的作用,以便相关领域研究者广泛深入地了解SCI后炎症反应的分子机制,并在此基础上寻找更优的生物学治疗方法。Spinal cord injury(SCI)is a serious central nervous system injury.Secondary injury is an important cause of poor prognosis in SCI,and inflammation is one of the main secondary injury.A lot of literatures have shown that inflammation cytokines and related signaling pathways,such as nuclear factor(NF)-κB,JAK/STAT and MAPK/ERK,regulate the inflammtion after SCI.They play a key role in the development of SCI.In this review,inflammation cytokines are classified into proinflammatory and anti-inflammatory factors according to their effects.This review focuses on the key proinflammatory factors interleukin 6(IL-6),tumor necrosis factor,and anti-inflammatory factors IL-4,IL-10 and reveals their roles in the process of SCI,so that researchers in related fields can understand the molecular mechanism of inflammation after SCI widely and deeply.Based on this,they may find better biological methods for the treatment of SCI.

关 键 词：脊髓损伤 炎症因子 白细胞介素 肿瘤坏死因子 

分 类 号：R651.2[医药卫生—外科学]