炔雌醇环丙孕酮片联合固本止崩汤治疗青春期崩漏患者的止血效果及对凝血功能、性激素水平的影响  

Hemostatic effect of Ethinylestradiol and Cyproterone Acetate Tablets combined with Guben Zhibeng Decoction in the treatment of adolescent patients with metrorrhagia and metrostaxis and its influence on blood coagulation function and sex hormone level

作　　者：阿依努尔·卡依提 邢金玲 Ainur Khaiti;XING Jinling(Department of Gynecology,Urumqi Hospital of Traditional Chinese Medicine,Xinjiang Uygur Autonomous Region,Urumqi,830000,China)

机构地区：[1]乌鲁木齐市中医医院妇科,新疆乌鲁木齐830000

出　　处：《中国医药导报》2021年第31期139-142,共4页China Medical Herald

基　　金：新疆维吾尔自治区中医民族医药科技人才培养项目(2017-03-14)。

摘　　要：目的研究炔雌醇环丙孕酮片联合固本止崩汤治疗青春期崩漏患者的止血效果及对凝血功能、性激素水平的影响。方法选取2019年2月至2021年3月乌鲁木齐市中医医院收治的96例青春期崩漏患者作为研究对象,并采用随机数字表法将其分为单一组、联合组,每组各48例。单一组采用炔雌醇环丙孕酮片治疗,而联合组采用炔雌醇环丙孕酮片联合固本止崩汤治疗,两组均治疗3个月经周期。比较两组的止血效果、治疗前后凝血功能指标[凝血酶时间(TT)、凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)]、性激素[雌二醇(E_(2))、孕酮(P)、卵泡刺激素(FSH)、黄体生成素(LH)]水平变化情况。结果治疗后,联合组控制出血时间、止血时间均短于单一组,差异有统计学意义(P<0.05)。治疗后两组TT、PT、APTT均长于治疗前,且联合组TT、PT、APTT均长于单一组,差异有统计学意义(P<0.05)。治疗后两组E_(2)、P、FSH、LH水平均低于治疗前,且联合组E_(2)、P、FSH、LH水平均低于单一组,差异有统计学意义(P<0.05)。结论炔雌醇环丙孕酮片联合固本止崩汤治疗青春期崩漏患者能有效提高止血效果,改善患者凝血功能和性激素水平。Objective To study the hemostatic effect of Ethinylestradiol and Cyproterone Acetate Tablets combined with Guben Zhibeng Decoction on adolescent patients with metrorrhagia and metrostaxis and its influence on blood coagulation function and sex hormone level.Methods A total of 96 adolescent patients with metrorrhagia and metrostaxis admitted to Urumqi Hospital of Traditional Chinese Medicine from February 2019 to March 2021 were selected as research subjects,and they were divided into single group and combined group by random number table method,with 48 cases in each group.The single group was treated with Ethinylestradiol and Cyproterone Acetate Tablets alone,while the combined group was treated with Ethinylestradiol and Cyproterone Acetate Tablets and Guben Zhibeng Decoction.Both groups were treated for three menstrual cycles.The hemostatic effect,blood coagulation function indexes(thrombin time[TT],prothrombin time[PT],activated partial thrombin time[APTT]),sex hormones(estradiol[E_(2)],progesterone[P],follicle-stimulating hormone[FSH],luteinizing hormone[LH])before and after treatment were compared between the two groups.Results After treatment,the bleeding control time and hemostasis time of combined group were shorter than those of single group,the differences were statistically significant(P<0.05).After treatment,TT,PT,and APTT of the two groups were longer than before treatment,and TT,PT,and APTT of the combined group were longer than those of single group,the differences were statistically significant(P<0.05).After treatment,the levels of E_(2),P,FSH,and LH in the two groups were lower than before treatment,and the levels of E_(2),P,FSH,and LH in combined group were lower than those in single group,the differences were statistically significant(P<0.05).Conclusion Ethinylestradiol and Cyproterone Acetate Tablets combined with Guben Zhibeng Decoction in the treatment of adolescent patients with metrorrhagia and metrostaxis can effectively improve hemostatic effect,blood coagulation function and sex hormone

关 键 词：青春期崩漏 炔雌醇环丙孕酮片 固本止崩汤 止血效果 凝血功能 性激素 

分 类 号：R271.12[医药卫生—中医妇科学]