Lepithiohydimerins A-D:Four Pairs of Neuroprotective Thiohydantoin Dimers Bearing a Disulfide Bond from Maca(Lepidium meyenii Walp.)  

作　　者：Xing-Rong Peng Ran-Ran Zhang Jun-Hong Liu Zhong-Rong Li Lin Zhou Ming-Hua Qiu 

机构地区：[1]State Key Laboratory of Phytochemistry and Plant Resources in West China,Kunming Institute of Botany,Chinese Academy of Sciences,Kunming,Yunnan,650201 China [2]University of the Chinese Academy of Sciences,Beijing 100049,China

出　　处：《Chinese Journal of Chemistry》2021年第10期2738-2744,共7页中国化学（英文版）

基　　金：supported by grants from the National Natural Science Foundation of China(No.31872675);Fund of State Key Laboratory of Phytochemistry and Plant Resources in West China(P2020-KF02).

摘　　要：Main observation and conclusion An HPLC-UV-guided separation was performed and four pairs of unprecedented macathiohydantoin dimers,lepithiohydimerins A—D(1—4)bearing a rare disulfide bond were isolated from the tubers of Maca.Their structures were unambiguously confirmed by NMR spectroscopic,X-ray crystallographic and electronic circular dichroism(ECD)analyses.At the concentration of 20μmol/L,compounds 2-1,2-2,and 4-1 increased the viability of PC12 cells with the cell viability at(72.06±1.14)%,(72.64±1.49)%,and(70.93±1.22)%,respectively.Furthermore,the serial concentration experiment showed that they can protect PC12 cells in a dose-dependent manner.

关 键 词：Lepidium meyenii Walp. Thiohydantoin dimers Natural products Structure elucidation Biological activity 

分 类 号：O62[理学—有机化学]