葛酮通络胶囊联合氟桂利嗪治疗椎基底动脉供血不足性眩晕的疗效观察  

Efficacy of Getong Tongluo Capsules Combined with Flunarizine in the Treatment of Vertigo of Vertebro-Basilar Insufficiency

作　　者：苏华[1] 孙金菊 郝强[2] SU Hua;SUN Jinju;HAO Qiang(Dept.of Pharmacy,Liaocheng Second People’s Hospital,Shandong Liaocheng 252601,China;Dept.of Neurology,Liaocheng Second People’s Hospital,Shandong Liaocheng 252601,China)

机构地区：[1]聊城市第二人民医院药学部,山东聊城252601 [2]聊城市第二人民医院神经内科,山东聊城252601

出　　处：《中国医院用药评价与分析》2021年第11期1331-1334,共4页Evaluation and Analysis of Drug-use in Hospitals of China

基　　金：山东省科技发展计划项目(No.2017WS0084)。

摘　　要：目的:探讨葛酮通络胶囊联合氟桂利嗪治疗椎基底动脉供血不足性眩晕的临床疗效。方法:将2019年6月至2020年12月聊城市第二人民医院收治的102例椎基底动脉供血不足性眩晕患者按照随机数字表法分为对照组和观察组,每组51例。对照组患者给予氟桂利嗪治疗,观察组患者给予葛酮通络胶囊联合氟桂利嗪治疗,两组均治疗2周。治疗后进行临床疗效评价;比较两组患者治疗前后基底动脉、左侧椎动脉和右侧椎动脉的血流速度,以及血清降钙素基因相关肽(CGRP)、内皮素-1(ET-1)水平。结果:观察组患者的临床总有效率为90.20%(46/51),明显高于对照组的70.59%(36/51),差异具有统计学意义(P<0.05)。观察组患者的头晕发作时间明显比对照组短,头晕发作频率明显比对照组低,差异均具有统计学意义(P<0.05)。治疗后,两组患者基底动脉、左侧椎动脉和右侧椎动脉的血流速度,以及血清CGRP水平均明显高于本组治疗前,且观察组患者上述指标水平均明显高于对照组,差异均具有统计学意义(P<0.05)。治疗后,两组患者的血清ET-1水平均明显低于本组治疗前,且观察组患者的血清ET-1水平明显低于对照组,差异均具有统计学意义(P<0.05)。结论:葛酮通络胶囊联合氟桂利嗪治疗椎基底动脉供血不足性眩晕的临床疗效显著,能够明显减轻患者的眩晕症状,改善椎基底动脉血流动力学和血清CGRP、ET-1水平。OBJECTIVE:To probe into the clinical efficacy of Getong Tongluo capsules combined with flunarizine in the treatment of vertigo of vertebro-basilar insufficiency.METHODS:Totally 102 patients with vergito of vertebro-basilar insufficiency admitted into Liaocheng Second People’s Hospital from Jun.2019 to Dec.2020 were extracted to be divided into control group and observation group via random number table,with 51 cases in each group.The control group was given flunarizine,while the observation group was given Getong Tongluo capsules combined with flunarizine,both groups were treated for 2 weeks.Evaluation of clinical efficacy was conduct after treatment;the blood flow velocity of basilar artery,left vertebral artery and right vertebral artery,levels of serum calcitonin gene-related peptide(CGRP)and endothelin-1(ET-1)before and after treatment were compared between two groups.RESULTS:The clinical total effective rate of observation group was 90.20%(46/51),which was significantly higher than that of the control group(70.59%,36/51),with statistically significant difference(P<0.05).The onset time of dizziness of observation group was significantly shorter than that of the control group,and the frequency of dizziness onset was significantly lower than that of the control group,with statistically significant differences(P<0.05).After treatment,the blood flow velocity of basilar artery,left vertebral artery and right vertebral artery,and the serum CGRP levels of both groups were significantly higher than those of before treatment,and the above-mentioned indicators of observation group were significantly higher than those of the control group,with statistically significant differences(P<0.05).After treatment,the serum ET-1 levels of both groups were significantly lower than those of before treatment,and the serum ET-1 level of observation group were significantly lower than that of the control group,with statistically significant differences(P<0.05).CONCLUSIONS:The efficacy of Getong Tongluo capsules combined with flunari

关 键 词：椎基底动脉供血不足 眩晕 葛酮通络胶囊 氟桂利嗪 疗效 血流动力学 

分 类 号：R932[医药卫生—生药学]