O-glycosylation pattern of the SARS-CoV-2 spike protein reveals an “O-Follow-N” rule  

作　　者：Wenmin Tian Delin Li Nan Zhang Guijie Bai Kai Yuan Haixia Xiao Feng Gao Yang Chen Catherine C.L.Wong George Fu Gao 

机构地区：[1]Center for Precision Medicine Multi-Omics Research,Peking University Health Science Center,Peking University,Beijing,China [2]School of Basic Medical Sciences,Peking University Health Science Center,Beijing,China [3]Laboratory of Protein Engineering and Vaccines,Tianjin Institute of Industrial Biotechnology,Chinese Academy of Sciences(CAS),Tianjin,China [4]Shanxi Academy of Advanced Research and Innovation,Taiyuan,Shanxi,China [5]Peking-Tsinghua Center for Life Sciences,Beijing,China [6]Peking University First Hospital,Beijing,China [7]Advanced Innovation Center for Human Brain Protection,Capital Medical University,Beijing,China [8]CAS Key Laboratory of Pathogen Microbiology and Immunology,Institute of Microbiology,Chinese Academy of Sciences,Beijing,China [9]National Institute for Viral Disease Control and Prevention,Chinese Center for Disease Control and Prevention(China CDC),Beijing,China

出　　处：《Cell Research》2021年第10期1123-1125,共3页细胞研究（英文版）

基　　金：We would like to thank Min Huang, Yue Zhou, Guanbo Wang, Minjie Tan for their assistance in mass spectrometry experiments. We would also like to thank Thermo Fisher Scientific for their support in collaboration. We would like to thank Shuaixin Gao, Yu Hu, Chao Su, Qihui Wang for their assistance in S protein purification. We thank Hui Wang and Beijing Institute of Biological Products Co., Ltd. for providing SARS-CoV-2 virions. We are grateful to Xuefei Yin (PMI Inc.), Yan Zhang, Wenfeng Zeng and Mingliang Ye for the assistance in the use of the software. We thank Yan Zhang and Xin Chen for their insightful discussion. This work was supported by the Fundamental Research Funds for the Central Universities (BMU2017YJ003, BMU2018XTZ002);the Research Funds from Health@InnoHK Program launched by the Innovation Technology Commission of the Hong Kong Special Administrative Region, the PKU-Baidu Fund (2019BD007);the Training Program of the Big Science Strategy Plan (2020YFE0202200);the National Program on Key Research Projects of China (2016YFD0500301);the Tianjin Synthetic Biotechnology Innovation Capacity Improvement Project (TSBICIP-KJGG-004).

摘　　要：Dear Editor,Severe acute respiratory syndrome coronavirus-2(SARS-CoV-2),the causative agent of coronavirus disease 2019(COVID-19),emerged in late 2019 and has since caused a pandemic.Although there have been extensive studies worldwide,our understanding of this newly emerged pathogen is far from sufficient.The pathogenesis of the SARS-CoV-2 infection is not fully understood,although a“two-stage”hypothesis was proposed in our previous study.

关 键 词：PATTERN acute RESPIRATORY 

分 类 号：R373[医药卫生—病原生物学]