Nanozymes for regulation of reactive oxygen species and disease therapy  

作　　者：Yujie Dai Yiming Ding Linlin Li 

机构地区：[1]Beijing Institute of Nanoenergy and Nanosystems,Chinese Academy of Sciences,Beijing 101400,China [2]School of Nanoscience and Technology,University of Chinese Academy of Sciences,Beijing 100049,China [3]Center on Nanoenergy Research,School of Chemistry and Chemical Engineering,School of Physical Science and Technology,Guangxi University,Nanning 530004,China

出　　处：《Chinese Chemical Letters》2021年第9期2715-2728,共14页中国化学快报（英文版）

基　　金：supported by the National Key R&D project from Minister of Science and Technology,China(No.2016YFA0202703);the National Nature Science Foundation(Nos.82072065,81471784);the Nature Science Foundation of Beijing(No.2172058);the National Youth Talent Support Program。

摘　　要：With high catalytic activity and stability,nanozymes have huge advantage in generating or eliminating the reactive oxygen species(ROS)due to their intrinsic enzyme-mimicking abilities,therefore attracting wide attention in ROS-related disease therapy.To better design nanozyme-based platforms for ROSrelated biological application,we firstly illustrate the catalytic mechanism of different activities,and then introduce different strategies for using nanozymes to augment or reduce ROS level for the applications in cancer therapy,pathogen infection,neurodegeneration,etc.Finally,the challenges and future opportunities are proposed for the development and application of nanozymes.

关 键 词：Nanozyme Reactive oxygen species(ROS) Cancer therapy PEROXIDASE OXIDASES Photodynamic therapy 

分 类 号：TB383.1[一般工业技术—材料科学与工程] R318.08[医药卫生—生物医学工程]