血清血管成生素样蛋白3与老年冠心病患者冠脉病变支数及冠脉狭窄程度的关系  

Clinical Significance of Serum ANGPTL3 in Evaluating the Number of Diseased Coronary Artery and the Degree of Coronary Artery Stenosis in Elderly Patients with CHD

作　　者：朱秋霞 雷景超 易欣[1,2,3] 郑晓新 刘畅[1,2,3] 蒋学俊 ZHU Qiu-xia;LEI Jing-chao;YI Xin;ZHENG Xiao-xin;LIU Chang;JIANG Xue-Jun(Department of Cardiology,Renmin Hospital of Wuhan University;Cardiovascular Research Institute,Wuhan University;Hubei Key Laboratory of Cardiology,Wuhan 430060,China)

机构地区：[1]武汉大学人民医院心内科,武汉430060 [2]武汉大学心血管病研究所,武汉430060 [3]心血管病湖北省重点实验室,武汉430060

出　　处：《微循环学杂志》2021年第4期32-36,42,共6页Chinese Journal of Microcirculation

基　　金：湖北省卫生健康委科研立项青年项目(WJ2019Q043)。

摘　　要：目的:观察老年冠心病患者血清血管生成素样蛋白3(ANGPTL3)水平变化,并探讨其对与老年冠心病患者冠脉病变支数及冠脉狭窄程度的关系。方法:选择2019-01—2019-12入住本院心血管内科接受冠状动脉造影、且年龄>65岁的老年患者130例,根据造影结果分为对照组(n=31)、单支病变组(n=45)、双支病变组(n=22)和多支病变组(n=32)。收集所有患者的年龄、血压、体重指数(BMI)、血常规、血糖、血脂等临床资料和生化指标。采用Gensini评分评价冠脉狭窄程度。采用酶联免疫吸附试验检测所有患者血清ANGPTL3的表达水平。采用多因素Logistic回归法分析冠心病的危险因素;采用多元线性回归分析Gensini评分与其它变量的相关性。结果:对照组患者血清ANGPTL3为(22.01±8.44)ng/ml。随着冠状动脉病变支数的增加,老年冠心病患者血清ANGPTL3的水平逐渐升高,分别为(25.45±13.42)、(33.40±14.55)和(37.61±15.52)ng/ml,差异具有统计学意义(P<0.001)。多因素Logistic回归分析结果显示高BMI和高血清ANGPTL3水平是老年冠心病的危险因素。多元线性回归分析显示ANGPTL3水平与Gensini评分相关。结论:老年冠心病患者血清ANGPTL3水平升高与其冠状动脉病变支数和冠脉病变严重程度有关。Objective:To observe the change of serum angiopoietin-like protein 3(ANGPTL3)level in elderly patients with coronary heart disease(CHD),and explore its clinical significance in evaluating the number of diseased coronary artery and the degree of coronary artery stenosis.Method:A total of 130 elderly patients older than 65 years were enrolled who were underwent coronary angiography from January to December 2019.They were divided into control group(n=31),single vessel disease group(n=45),double-vessel disease group(n=22)and multi-vessel disease group(n=32)according to the angiography.The whole patients'age,blood pressure,body mass index(BMI),blood routine,blood glucose,blood lipids and other clinical data were collected.The Gensini score was used to evaluate the degree of coronary artery stenosis.Enzyme-linked immunosorbent assay was used to detect the expression level of serum ANGPTL3 in all patients.Multivariate logistic regression was used to analyze the risk factors of CHD.Multiple linear regressions was used to analyze the correlation between Gensini score and other variables.Results:The serum ANGPTL3 of the control group was(22.01±8.44)ng/ml.With the increase of the number of diseased coronary artery,the serum ANGPTL3 levels of elderly patients with CHD were gradually increased(25.45±13.42),(33.40±14.55)and(37.61±15.52)ng/ml respectively.Multivariate logistic regression analysis showed that in addition to increased BMI,increased serum ANGPTL3 levels was also risk factor for CHD in the elderly.Multiple linear regression analysis also found that ANGPTL3 was related to Gensini score.Conclusion:The increase of serum ANGPTL3 level is related to the number of diseased coronary artery and the severity in elderly patients with CHD.

关 键 词：血管生成素样蛋白3 冠心病 老年患者 冠状动脉狭窄 病变支数 

分 类 号：R541.4[医药卫生—心血管疾病]