帕洛诺司琼联合小剂量氟哌利多止吐对妇科腹腔镜手术患者QT间期的影响  

Effect of panolosetron combined with lowdose droperidol on QT interval in patients undergoing gynecological laparoscopic surgery

作　　者：白冬冬 郭志佳[2] 王春燕[2] Bai Dongdong;Guo Zhijia;Wang Chunyan(School of Anesthesiology,Shanxi Medical University,Taiyuan 030001,China;Department of Anesthesiology,the First Hospital of Shanxi Medical University,Taiyuan 030012,China)

机构地区：[1]山西医科大学麻醉学院,太原030001 [2]山西医科大学第一医院麻醉科,太原030012

出　　处：《国际麻醉学与复苏杂志》2021年第11期1195-1198,共4页International Journal of Anesthesiology and Resuscitation

摘　　要：目的研究帕洛诺司琼联合小剂量氟哌利多止吐对患者QT间期的影响。方法选取择期行腹腔镜手术治疗的妇科患者100例,采用随机数字表法分为氟哌利多组(F组)和帕洛诺司琼联合氟哌利多组(P+F组),每组50例。F组患者在气管插管后5 min静脉注射1 mg氟哌利多,P+F组患者在气管插管后5 min静脉注射0.075 mg帕洛诺司琼和1 mg氟哌利多。记录两组患者给药前(T_(0))、给药后5 min(T_(1))、给药后10 min(T_(2))、给药后20 min(T_(3))时的MAP、心率、BIS以及12导联ECG,测量QT间期并根据矫正公式计算出校正QT间期(correct QT interval,QTc间期)。记录患者术后24 h恶心呕吐的严重程度以及其他不良反应发生率。结果两组患者年龄、BMI、ASA分级、手术时间比较差异无统计学意义(P>0.05)。T_(0)~T_(3)时,两组患者心率、MAP、BIS、QTc间期比较,差异均无统计学意义(P>0.05)。各时点两组间QTc间期变化差异无统计学意义(P>0.05);与T_(0)时点比较,两组患者T_(1)时点QTc间期略微延长,差异有统计学意义(P<0.05)。P+F组术后24 h恶心呕吐严重程度低于F组(P<0.05),两组患者术后其他不良反应的发生率差异无统计学意义(P>0.05)。结论与单纯使用氟哌利多相比,帕洛诺司琼联合小剂量氟哌利多止吐并没有进一步延长患者的QT间期,且两种药物合用发生恶心呕吐的严重程度较低。Objective The research aims to study the effect of palonosetron combined with low⁃dose droperidol on QT inter⁃val.Methods One hundred with gynecological diseases undergoing laparoscopic surgery were divided into droperidol group(group F)and palonosetron plus droperidol group(group P+F)according to the random number table method(n=50).In group F,1 mg droperi⁃dol was intravenously injected in patients 5 min after tracheal intubation,while in group P+F,0.075 mg palonosetron and 1 mg droperi⁃dol were injected in patients 5 min after tracheal intubation.The mean arterial pressure,heart rate,bispectral index(BIS)and 12 lead electrocardiogram were recorded before administration(T_(0)),5 min(T_(1)),10 min(T_(2))and 20 min(T_(3))after administration.QT interval was measured and correct QT(QTc)interval was calculated according to the correction formula.The severity of nausea and vomiting 24 h af⁃ter operation and the incidence of other adverse reactions were recorded.Results There was no significant difference in age,body mass index(BMI),American Society of Anesthesiologists(ASA)classification,and operation time between the two groups(P>0.05).There was no significant difference in heart rate,mean arterial pressure(MAP),BIS and QTc interval between the two groups during the whole observation period(P>0.05).There was no significant difference in QTc interval changes between the two groups(P>0.05);at T_(1),QTc interval values of group F and group P+F were slightly prolonged,but the difference was statistically significant compared with T_(0)(P<0.05).The severity of nausea and vomiting 24 h after operation in group P+F was lower than that in group F(P<0.05);there was no significant difference in incidences of other adverse reactions between the two groups(P>0.05).Conclusions Compared with dro⁃peridol alone,palonosetron combined with low⁃dose droperidol did not further prolong the QT interval,and the antiemetic effect of the two drugs was better than that of droperidol alone.

关 键 词：QT间期 帕洛诺司琼 氟哌利多 术后恶心呕吐 妇科手术 腹腔镜检查术 

分 类 号：R614[医药卫生—麻醉学]