超声传感器与压差式传感器肺功能仪评估儿童肺功能的差异性分析  

Difference analysis of pulmonary function in children by ultrasonic sensor and differential pressure sensor

作　　者：侯晓玲[1] 杨世青 许巍[1] 皇惠杰 李珍[1] 任亦欣[1] 向莉[1] HOU Xiao-ling;YANG Shi-qing;XU Wei;HUANG Hui-jie;LI Zhen;REN Yi-xin;XIANG Li(Department of Allergy,National Center for Children’s Health,Beijing Children’s Hospital,Capital Medical University,Key Laboratory of Pediatric Major Diseases,Ministry of Education,Beijing 100045,China)

机构地区：[1]国家儿童医学中心,首都医科大学附属北京儿童医院过敏反应科,儿科重大疾病研究教育部重点实验室,北京100045

出　　处：《生物医学工程与临床》2021年第6期681-686,共6页Biomedical Engineering and Clinical Medicine

基　　金：北京市科学技术委员会计划项目(Z15110004015030);北京市医院管理局儿科学科协同发展中心儿科专项(XTCX201818)。

摘　　要：目的探讨采用超声传感器与压差传感器肺功能仪评估儿童肺功能的差异性,初步建立超声传感器肺功能仪评估儿童肺通气功能的适用性参考标准。方法选择首都医科大学附属北京儿童医院2016年12月至2018年1月能同期配合完成超声传感器肺功能仪与压差传感器肺功能仪行肺功能检测的受试儿童235例,其中男性169例,女性66例;年龄5.34~17.00岁,平均年龄9.38岁。比较两种方法所测肺通气功能参数包括第1秒用力呼气容积占用力肺活量百分比(FEV1/FVC)、用力肺活量占预计值的百分比(FVC%pred)、第1秒用力呼气容积占预计值的百分比(FEV1%pred)、最大呼气流量占预计值的百分比(FEF%pred)、用力呼出25%、50%、75%肺活量时瞬间流量占预计值的百分比(FEF25%pred、FEF50%pred、FEF75%pred)及最大呼气中期流量占预计值的百分比(MMEF%pred)的差异性,分析判定采用超声传感器肺功能仪判断肺通气功能障碍的适用性参考标准。结果支气管哮喘者、闭塞性细支气管炎者、阻塞性睡眠呼吸暂停低通气综合征及体检正常儿童中,在肺功能受损程度分布(肺功能阻塞程度和小气道功能障碍)上,差异有显著统计学意义(P=0.00、0.00)。超声传感器肺功能仪与压差传感器肺功能仪的肺功能各参数比较,肺通气指标FVC%pred、FEV1%pred、FEF%pred、FEF25%pred、FEF50%pred、FEF75%pred,差异均有显著统计学意义(P<0.01),而FEV1/FVC及MMEF%pred指标,差异无统计学意义(P>0.05)。进一步以压差法为金标准,采用受试者工作特性(ROC)曲线法,获得在阻塞性气道疾病的判断时,超声传感器肺功能仪所测肺功能FVC%pred、FEV1%pred、FEF%pred、FEF25%pred、FEF50%pred、FEF75%pred的正常界值分别为73.5%、79.5%、75.5%、62.5%、58.5%、79.0%。结论超声传感器肺功能仪测定儿童肺通气功能结果,与压差传感器肺功能仪测定值间不宜直接互换,建议可应用所在实验室的一些实践参�Objective To compare the difference between ultrasonic sensor and differential pressure sensor in evaluating pulmonary function of children,and establish applicability standard for ultrasonic flowmeter to evaluate children pulmonary ventilation.Methods From December 2016 to January 2018,235 children performed pulmonary function testing by ultrasonic sensors and differential pressure sensors were enrolled,which included 169 males and 66 females,aged 5.34-17.00 years old with mean age of 9.38 years old.The differences of lung ventilation function parameters measured by 2 methods were compared,including forced expiratory volume in one second to forced vital capacity(FEV1/FVC),FVC percentage of predicted value(FVC%pred),FEV1 percentage of predicted value(FEV1%pred),forced expiratory flow(FEF)percentage of predicted value(FEF%pred),forced expiratory flow at 25%(FEF25%pred),50%(FEF50%pred)and 75%(FEF75%pred),percentage of maximum midexpiratory flow percentage to predicted value(MMEF%pred).The applicability of ultrasonic sensor in evaluating pulmonary function ventilation dysfunction was analyzed and determined.Results There were significant differences in distribution of pulmonary function impairment(pulmonary function obstruction and small airway dysfunction)(P=0.00,0.00)in children with bronchial asthma,bronchiolitis obliterans,obstructive sleep apnea syndrome than in children with normal physical examination.The pulmonary function parameters of ultrasound method and differential pressure method were significantly different in pulmonary ventilation index,including FVC%pred,FEV1%pred,PEF%pred,FEF25%pred,FEF50%pred,FEF75%pred(P<0.01),while there was no statistically significant difference in FEV1/FVC and MMEF%pred(P>0.05).Furthermore,the differential pressure method was set as gold standard,the receiver operating characteristic(ROC)curve method was adopted to obtain normal thresholds of pulmonary function parameters.The normal limits of FVC%pred,FEV1%pred,FEF%pred,FEF25%pred,FEF50%pred and FEF75%pred were 73.5%,79.5%,7

关 键 词：儿童 肺功能 压差传感器 超声传感器 肺通气功能 

分 类 号：R725.6[医药卫生—儿科] R443.6[医药卫生—临床医学]