学龄儿童非感染急性腹型荨麻疹的治疗体会  

Experience in the Treatment of Non-infectious Acute Abdominal Urticaria in School-age Children

作　　者：付伟[1] 王浩[1] FU Wei;WANG Hao(Department of Pediatrics,Huadu District Maternal and Child Health Hospital,Guangzhou,Guangdong 510800)

机构地区：[1]广州市花都区妇幼保健院儿科,广东广州510800

出　　处：《智慧健康》2021年第22期39-41,共3页Smart Healthcare

摘　　要：目的总结单用糖皮质激素,糖皮质激素、抗组胺药物联用,糖皮质激素、抗组胺药物、氢溴酸山莨菪碱注射液联合应用治疗学龄期儿童非感染急性腹型荨麻疹的治疗体会,提出最佳治疗方法.方法采用病例随机对照研究的方法,按照纳入标准纳入120名患儿.随机分为3组,每组40例.治疗A组仅给予糖皮质激素(静脉滴注强的松当量1mg/kg/d),治疗过程中无其他治疗干预.治疗B组,给予糖皮质激素(静脉滴注强的松当量1mg/kg/d)、抗组胺药物(氯雷他定分散片5mg/d)联用,治疗过程中无其他治疗干预.治疗C组,给予糖皮质激素(静脉滴注强的松当量1mg/kg/d)、抗组胺药物(口服氯雷他定分散片5mg/d)、肌肉注射氢溴酸山莨菪碱注射液(0.1mg/kg)联用,治疗过程中无其他治疗干预.治疗结束后收集皮疹消失时间、腹痛消失时间,住院天数等数据,并进行统计学分析.结果治疗B组皮疹消失时间与A组相比时间缩短,差异有统计学意义(P<0.05),治疗C组腹痛消失时间与A组相比时间缩短,具有统计学意义(P<0.05),治疗C组腹痛消失时间与B组相比时间缩短,差异具有统计学意义(P<0.05).治疗B、C组的住院时间与治疗A组相比,时间缩短,差异有统计学意义(P<0.05).结论急性腹型荨麻疹,皮疹瘙痒明显、腹痛剧烈,治疗上,早期缓解症状,能减轻患儿痛苦,缓解家长焦虑.本研究证实糖皮质激素、抗组胺药物、氢溴酸山莨菪碱注射液联合应用,能明显缩短学龄期非感染急性腹型荨麻疹引起的瘙痒、腹痛时间,缩短住院时间.建议对此类病人给予糖皮质激素、抗组胺药物、氢溴酸山莨菪碱注射液联合应用治疗.Objective To summarize the treatment experience on non-infectious acute abdominal urticaria in school-age children using glucocorticoid alone,combination of glucocorticoid and antihistamine drug,combination of glucocorticoid、antihistamine drug and anisodamine hydrobromide injection.Methods A case-controlled randomized study was conducted,and 120 children were enrolled according to the inclusion criteria.They were randomly divided into 3 groups with 40 cases in each group.Treatment of group A was only given glucocorticoid(intravenous infusion of prednisone equivalent 1mg/kg/d),and no other therapeutic intervention was given during the treatment.Treatment of group B was given glucocorticoid(intravenous infusion of prednisone equivalent 1mg/kg/d)and antihistamine(loratadine dispersive tablet 5mg/d),without other therapeutic intervention.Group C was given glucocorticoid(intravenous drip of prednisone equivalent 1mg/kg/d),antihistamine(oral loratadine dispersive tablets 5mg/d)and intramuscule injection of anisodamine hydrobromide injection(0.1mg/kg),without other therapeutic intervention.After the treatment,the data of the disappearance time of rash,the disappearance time of abdominal pain and the length of hospital stay were collected and analyzed statistically.Results The disappearance time of the rash in group B was shorter than that in group A,and the difference was statistically significant(P<0.05).The disappearance time of abdominal pain in group C was shorter than that in group A,with statistical significance(P<0.05).There was no significant difference in the disappearance time of abdominal pain between group C and group B(P>0.05).The length of hospital stay in treatment group B and C was shorter than that in treatment group A,with statistical difference(P<0.05).Conclusion On acute abdominal urticaria with pruritic rash and severe abdominal pain,in terms of treatment,early relief of symptoms can reduce the pain of children and relieve the anxiety of parents.This study confirmed the combination of glucocortico

关 键 词：学龄儿童 急性 非感染性 腹型荨麻疹 

分 类 号：R758.24[医药卫生—皮肤病学与性病学]