间接法建立长春地区健康成人血清前清蛋白参考区间及与国内其他地区参考区间的比较  

Establishment of Reference Intervals of Serum Prealbumin among Healthy Adults in Changchun Area by Indirect Method and Comparison with other Regions in China

作　　者：孙泽宇 柴佳彤 周琪[2] 许建成[1] SUN Ze-yu;CHAI Jia-tong;ZHOU Qi;XU Jian-cheng(Department of Clinical Laboratory,the First Hospital of Jilin University,Changchun 130021,China;Department of Pediatrics,the First Hospital of Jilin University,Changchun 130021,China)

机构地区：[1]吉林大学第一医院检验科,吉林长春130021 [2]吉林大学第一医院儿科,吉林长春130021

出　　处：《现代检验医学杂志》2021年第6期148-151,共4页Journal of Modern Laboratory Medicine

基　　金：吉林省科技发展计划项目医药健康专项(20190304110YY)。

摘　　要：目的采用间接法建立长春地区血清前清蛋白(prealbumin,PA)参考区间,并验证其适用性。方法调取2020年6月~11月吉林大学第一医院实验室信息系统中14003例健康体检者的PA检测结果。偏度-峰度检验分析数据正态性,杜奇法剔除离群值后入组13772例,其中男性7502例,女性6270例。根据性别、年龄将受检者分组(男女各6组:18~30岁,31~40岁,41~50岁,51~60岁,61~70岁和>70岁),Z检验比较组间差异,非参数方法计算参考区间。将获得的参考区间与国内其他地区参考区间进行比较并验证。结果男女PA差异有统计学意义(Z=77.48,Z*=22.72)。男性在70岁之后差异有统计学意义,其参考区间分别为230~400mg/L(18~70岁),190~340mg/L(>70岁)。女性无年龄差异,参考区间为190~320mg/L(18~89岁)。对建立的PA参考区间进行验证符合标准。结论长春地区健康成人血清PA参考区间存在性别和年龄差异。间接法建立参考区间简便可行,适于临床实验室推广和应用。Objective To establish reference intervals of serum prealbumin(PA)in Changchun by using the indirect method and verify the applicability.Methods The PA test results of 14003 healthy examinees were selected from the laboratory information system(LIS)of the First Hospital of Jilin University from June to November 2020.The skewness~kurtosis test was used to analyze the normality of the data,after eliminating outliers,13772 cases were enrolled of which 7502 were males and 6270 were females.According to gender and age,the subjects were divided into 6 age groups for males and females(18~30 years,31~40 years,41~50 years,51~60 years,61~70 years and>70 years).Z-test was used to compare the differences between groups,and the reference intervals were calculated by non~parametric method.Compared the reference interval obtained with those in other regions of China.Results There was a statistically significant difference in PA between males and females(Z=77.48,Z*=22.72).The difference in males after 70 years old was statistically significant,with the reference intervals of 230~400mg/L(18~70 years old)and 190~340mg/L(>70 years old),respectively.There was no age difference in females,and the reference interval was 190~320mg/L(18~89 years old).Validation of reference intervals met standards.Conclusion There are sex and age differences of serum PA reference intervals among healthy adults in Changchun.It is simple and feasible to use the indirect method to establish the reference intervals,which is suitable for popularization and application in various clinical laboratories.

关 键 词：间接法 前清蛋白 年龄 性别 参考区间 

分 类 号：R446.112[医药卫生—诊断学]