长链非编码RNA调控CD4^(+)T淋巴细胞增殖分化和在免疫性疾病中的最新研究进展  

Roles of lncRNA in Regulating the Proliferation,Differentiation of CD4^(+)T Lymphocytes and Immune Diseases

作　　者：刘立民[1] 刘雪香[1] 邹燕[1] 黄志卓[1] LIU Li-min;LIU Xue-xiang;ZOU Yan;HUANG Zhi-zhuo(Department of Medical Laboratory,Liuzhou Worker Hospital/Fourth Affiliated Hospital of Guangxi Medical University,Guangxi Liuzhou 545005,China)

机构地区：[1]柳州市工人医院/广西医科大学第四附属医院医学检验科,广西柳州545005

出　　处：《现代检验医学杂志》2021年第6期200-204,共5页Journal of Modern Laboratory Medicine

基　　金：广西重点研发计划项目(桂科AB17292055);广西高校中青年教师科研基础能力提升项目(2019KY0156)。

摘　　要：长链非编码RNA(long non-coding RNA,lncRNA)是长度大于200nt的非编码RNA,其作用机制涉及染色质重塑、DNA转录及转录后修饰、蛋白翻译及翻译后调节,与免疫性疾病关系密切。CD4^(+)T淋巴细胞在适应性免疫反应中发挥重要调控作用,体内的CD4^(+)T淋巴细胞亚群相互配合维持免疫平衡。CD4^(+)T淋巴亚群的比例失调,可能导致免疫失衡,甚至引起免疫性疾病。该文主要阐述lncRNA及其在CD4^(+)T淋巴细胞的增殖分化和免疫性疾病中的调控作用。Long non-coding RNA(lncRNA)is a type of non-coding RNA with a length greater than 200nt.The mechanism playing by lncRNA involves chromatin remodeling,DNA transcription and post-transcriptional modification,protein translation and post-translational regulation,and it would be closely related to immune diseases.CD4^(+)T lymphocytes play a key regulatory role in the adaptive immune response,whose subsets were interacted with each other to maintain immune balance.Disproportionate CD4^(+)T lymphocytes subsets may cause immune imbalance or even immune diseases.In this article,summarize roles of lncRNA in regulating the proliferation,differentiation of CD4^(+)T lymphocytes,and immune diseases.

关 键 词：长链非编码RNA CD4^(+)T淋巴细胞 免疫 表观遗传 

分 类 号：Q756[生物学—分子生物学] R446.6[医药卫生—诊断学]