重复经颅磁刺激联合黄连温胆汤对痰热内扰型不寐患者睡眠质量和焦虑情绪的影响  

Effects of repetitive transcranial magnetic stimulation combined with Huanglian Wendan Decoction on sleep quality and anxiety mood in patients with phlegm-heat attacking internally type of insomnia

作　　者：高千仞[1] 洪营东[2] 吴文秀[1] 张益伟[1] 罗京[3] 王芳[1] GAO Qianren;HONG Yingdong;WU Wenxiu;ZHANG Yiwei;LUO Jing;WANG Fang(Department of Neurology,The Affiliated People′s Hospital of Fujian University of Traditional Chinese Medicine,Fuzhou 350004,China;Department of General Practice,The Affiliated People′s Hospital of Fujian University of Traditional Chinese Medicine,Fuzhou 350004,China;Office of Academic Research,The Affiliated People′s Hospital of Fujian University of Traditional Chinese Medicine,Fuzhou 350004,China)

机构地区：[1]福建中医药大学附属人民医院神经内科,福建福州350004 [2]福建中医药大学附属人民医院全科医疗科,福建福州350004 [3]福建中医药大学附属人民医院科研处,福建福州350004

出　　处：《中国现代医生》2021年第28期46-49,共4页China Modern Doctor

基　　金：福建省卫生计生科研人才培养项目(2017-2-50)。

摘　　要：目的观察联合黄连温胆汤对痰热内扰型不寐患者连续治疗4周停止后1个月内患者睡眠质量和焦虑情绪的影响。方法研究纳入2019年12月至2021年5月福建中医药大学附属人民医院神经内科门诊及住院部痰热内扰型不寐受试者53例,按随机数字表法分为试验组27例和对照组26例,试验组采用rTMS联合黄连温胆汤治疗,对照组采用黄连温胆汤治疗,两组治疗4周,随访4周。观察治疗前、第4周及第8周的匹茨堡睡眠质量指数量表(PSQI)评分及汉密尔顿焦虑量表(HAMA)评分的变化情况。结果两组患者第4周和第8周的PSQI评分和HAMA评分均显著低于治疗前。试验组第8周的PSQI评分高于第4周;对照组第8周的PSQI评分和第4周相当;两组第8周的HAMA评分和第4周相当。结论在停止rTMS联合黄连温胆汤治疗后,受试者在治疗期间已被改善的睡眠质量出现了一定程度下降,但并未下降到治疗前的水平;而在治疗期间已被改善的焦虑情绪状态能够稳定维持1个月,并未出现下降。Objective To observe the effects of repetitive transcranial magnetic stimulation(rTMS) combined with Huanglian Wendan Decoction on sleep quality and anxiety mood in patients with phlegm-heat attacking internally type of insomnia in 1 month after continuous treatment for 4 weeks. Methods A total of 53 subjects with phlegm-heat attacking internally type of insomnia who were admitted to the Department of Outpatient and the Department of Inpatient of Department of Neurology,The Affiliated People′s Hospital of Fujian University of Traditional Chinese Medicine from December 2019 to May 2021 were enrolled in this study,and they were divided into the experimental group(n=27) and the control group(n=26). The experimental group was treated with rTMS combined with Huanglian Wendan Decoction,while the control group was treated with Huanglian Wendan Decoction. The two groups were treated for 4 weeks and followed up for 4 weeks. The changes of Pittsburgh Sleep Quality Index( PSQI) scores and Hamilton Anxiety Scale(HAMA) scores were observed before treatment,at week 4 and at week 8. Results Compared with before treatment,the PSQI scores and HAMA scores at week 4 and week 8 in the 2 groups were significantly lower than those before treatment. The PSQI score of the experimental group at week 8 was higher than that at week 4.The PSQI score of the control group at week 8 was similar to that at week 4.The HAMA scores at week 8 in both groups were similar to those at week4. Conclusion After discontinuation of rTMS combined with Huanglian Wendan Decoction,the subjects’ sleep quality,which had been improved during the treatment period,decreased to some extent,but did not decrease to the level before treatment.The anxiety status,which had been improved during treatment,remained stable for one month and did not decrease.

关 键 词：失眠 重复经颅磁刺激 黄连温胆汤 PSQI HAMA 

分 类 号：R493[医药卫生—康复医学]