液体通气治疗急性呼吸窘迫综合征研究进展  

Research advances in liquid ventilation in treatment of acute respiratory distress syndrome

作　　者：程志鹏 梁志欣[1] CHENG Zhipeng;LIANG Zhixin(Department of Respiration and Critical Care Medicine,the First Medical Center,Chinese PLA General Hospital,Beijing 100853,China)

机构地区：[1]解放军总医院第一医学中心呼吸与危重症医学科,北京100853

出　　处：《解放军医学院学报》2021年第9期988-992,共5页Academic Journal of Chinese PLA Medical School

基　　金：军事医学创新工程专项(16CXZ041)。

摘　　要：急性呼吸窘迫综合征(acute respiratory distress syndrome,ARDS)是呼吸系统急重症,纠正低氧状态是ARDS救治重点。应用呼吸机进行机械通气是当前ARDS最主要的呼吸支持手段,但治疗效果仍不能令人满意。以全氟化碳(perfluorocarbon,PFC)作为液态呼吸介质的液体通气(liquid ventilation,LV)技术是ARDS治疗的研究方向之一。PFC在常温下为无色无味的透明液体,性质稳定,同时其表面张力低,携氧能力强。动物试验表明,液体通气可明显改善气体交换和肺顺应性,具有良好的应用前景,但临床研究相对滞后。本文对液体通气的发展过程、液体通气治疗ARDS的作用机制、疗效以及应用前景等进行综述。Acute respiratory distress syndrome(ARDS)is an acute and severe respiratory disease,and correcting hypoxia is the focus of ARDS treatment.The use of ventilator for mechanical ventilation is currently the most important respiratory support method for ARDS,but the treatment effect is still unsatisfactory.Liquid Ventilation(LV)technology using perfluorocarbon(PFC)as a liquid breathing medium is one of the new treatment methods for ARDS.Perfuorocarbons(PFCs)are colorless and odorless transparent liquids at room temperature with stable properties.At the same time,perfuorocarbons have low surface tension and strong oxygen carrying capacity.Animal experiments have shown that liquid ventilation can significantly improve gas exchange and lung compliance,and has good application prospects.This article will review the development process of liquid ventilation,the efficacy,mechanism of action and the application prospects of liquid ventilation in the treatment of ARDS.

关 键 词：急性呼吸窘迫综合征 机械通气 呼吸介质 液体通气 全氟化碳 

分 类 号：R563.8[医药卫生—呼吸系统]