三七总皂苷白蛋白微球注射液在家兔体内的药物代谢动力学研究  

Pharmacokinetic of Panax Notoginseng Albumin Microspheres Injection in Rabbits

作　　者：杨姗 陈汝玲 吴静澜 田孟斌 杨光锦 YANG Shan;CHEN Ru-ling;WU Jing-lan;TIAN Meng-bin;YANG Guang-jin(Guizhou University of Traditional Chinese Medicine,Guiyang,Guizhou 550025,China)

机构地区：[1]贵州中医药大学,贵州贵阳550025

出　　处：《贵州中医药大学学报》2021年第6期21-26,共6页Journal of Guizhou University of Traditional Chinese Medicine

基　　金：贵州科技合作计划项目,项目编号:黔科合LH[2015]7280号;贵州省普通高等学校中药民族药(苗药)新剂型新制剂工程研究中心,项目编号:黔教合KY字[2014]22号;贵州省国内一流建设学科项目,项目编号:GNYL[2017]008号;贵州省一流专业(中药学)建设项目,项目编号:黔高教发[2017]158号。

摘　　要：目的:对三七总皂苷白蛋白微球注射液(PNS-BSA-MS-inj)在家兔体内的药物代谢动力学进行研究。方法:以新西兰大白兔为模型动物,以血塞通注射液为对照制剂,关节腔注射PNS-BSA-MS-inj和血塞通注射液,运用UPLC-MS/MS技术检测家兔体内人参皂苷Rb1的血药浓度变化,同时建立人参皂苷Rb1的血浆定量分析方法。利用DAS 2.0软件分析PNS-BSA-MS-inj和血塞通注射液的药物代谢动力学参数差异。结果:家兔关节腔注射PNS-BSA-MS-inj和血塞通注射液后,药物代谢动力学参数如下:半衰期(t_(1/2))分别为59.350 h和35.694 h,药峰浓度(C_(max))分别为34.340μg/mL和42.340μg/mL;达峰时间(t_(max))分别12 h和1 h;药时曲线下面积(AUC_(0-∞))分别为2265.702 mg/(L·h^(-1))和1961.411 mg/(L·h^(-1));PNS-BSA-MS-inj的相对生物利用度为116%。结论:与血塞通注射液相比,PNS-BSA-MS-inj能显著提高药物在家兔体内的滞留时间,并能提高药物在家兔体内的生物利用度,说明PNS-BSA-MS-inj具有缓释效果。Objective:To investigate the pharmacokinetic of Panax notoginsenoside albumin microspheres injection(PAMI)in rabbits.Methods:The PAMI and Xuesaitong injection(XI)were injected into the joint cavity of rabbits with XI as a control preparation.The concentration of ginsenoside Rb1 of plasma in PAMI and XI groups were detected by using UPLC-MS/MS,as well as the quantitative analysis method was established.The DAS 2.0 software was used to analyze the pharmacokinetic parameter.Results:After injection of PAMI and XI in rabbits,the pharmacokinetic parameters were changed significantly.Conclusions:PAMI may increase the retention time and bioavailability in vivo of rabbits,suggesting that it has sustained-release effect.

关 键 词：三七总皂苷 白蛋白微球 关节腔注射 人参皂苷RB1 UPLC-MS/MS 

分 类 号：R285[医药卫生—中药学]