参蛤定喘方治疗稳定期慢性阻塞性肺疾病临床研究  

Clinical Study of Shenge Dingchuan Formula(参蛤定喘方)on Chronic Obstructive Pulmonary Disease at Stable Stage

作　　者：姚婧 陈凯 吴颢昕[2] 张文苑 YAO Jing;CHEN Kai;WU Haoxin;ZHANG Wenyuan(Suzhou Hospital of Integrated Traditional Chinese and Western Medicine,Suzhou 215100,China;Nanjing University of Chinese Medicine,Nanjing 210046,China)

机构地区：[1]苏州市中西医结合医院,江苏苏州215100 [2]南京中医药大学,江苏南京210046

出　　处：《山东中医杂志》2021年第12期1337-1342,共6页Shandong Journal of Traditional Chinese Medicine

基　　金：苏州市科技发展计划基金资助项目(编号:SYSD2018204);苏州市中西医结合医院院级课题(编号:YJ2018003)。

摘　　要：目的:探讨参蛤定喘方治疗慢性阻塞性肺疾病(COPD)稳定期患者的临床疗效及作用机制。方法:将60例确诊为COPD并处于稳定期的患者,根据随机数字表法分为观察组和对照组各30例。两组患者均给予沙美特罗替卡松粉吸入剂规范治疗,对照组加用淀粉胶囊安慰剂口服,观察组加用参蛤定喘方的胶囊制剂口服,两组均足量用药3个月。比较两组患者治疗前后的中医证候积分、肺功能变化情况、临床COPD问卷(CCQ)评分、T淋巴细胞亚群水平,记录不良反应及安全性理化指标,评价临床疗效,评估安全性。结果:观察组治疗有效率高于对照组(P<0.05)。治疗后,两组各观察指标均有所改善,观察组中医证候积分、CCQ评分低于对照组(P<0.05);观察组T淋巴细胞亚群水平优于对照组(P<0.05);两组肺功能比较,差异无统计学意义(P>0.05),但观察组的肺功能指标改善值高于对照组(P<0.05)。结论:参蛤定喘方治疗稳定期COPD,能够有效改善患者临床症状,降低气道黏液高分泌状态,稳定肺功能水平,调节机体免疫,提高患者生活质量。Objective:To investigate the clinical effect and the underlying mechanism of Shenge Dingchuan Formula(参蛤定喘方)in the treatment of chronic obstructive pulmonary disease(COPD)at the stable stage.Methods:Sixty patients diagnosed with COPD at the stable stage were divided into observation group and control group using a random number table,with 30 patients in each group.Patients in the two groups were both treated with salmeterol xinafoateand fluticasone propionate powder for inhalation.Besides,patients in the control group were given placebos,starch-containing capsules,while patients in the observation group were given with Shenge Dingchuan Formula capsules.Both groups were treated for 3 months.The traditional Chinese medicine(TCM)syndrome scores,pulmonary function,clinical COPD questionnaire(CCQ)scores and T lymphocyte level changes of the two groups,before and after treatment were observed.The clinical efficacy of both groups were evaluated,adverse reactions and laboratory index were recorded to evaluate safety.Results:The effective rate of the observation group was higher than that of the control group(P<0.05).After the treatment,the observed indexes of the two groups were improved,TCM syndrome scores and CCQ scores of the observation group were lower than those of the control group(P<0.05).The levels of T lymphocyte subpopulation of the observation group were higher than those of the control group(P<0.05).The difference of lung function between the two groups was insignificant(P>0.05),but the improvement of lung function in the observation group was higher than that in the control group(P<0.05).Conclusion:Shenge Dingchuan Formula could improve the clinical symptoms of patients with COPD,reduce airway mucus hypersecretion,stabilize pulmonary function,regulate body immunity,and has obvious effect on improving quality of life in patients.

关 键 词：参蛤定喘方 慢性阻塞性肺疾病 稳定期 肺功能 T淋巴细胞 

分 类 号：R259.63[医药卫生—中西医结合]