血清Cys-C、β2-MG、Fetuin-A与老年糖尿病肾病的相关性研究  

Study on correlation between serum Cys-C,β2-MG,Fetuin-A and elderly diabetic nephropathy

作　　者：肖改娥[1] 马莹[1] 李婷[1] 成存相 崔娟 XIAO Gai’e;MA Ying;LI Ting;CHENG Cunxiang;CUI Juan(Department of Laboratory Medicine,Xi’an Central Hospital,Xi'an,710003,China)

机构地区：[1]西安市中心医院检验科,西安710003

出　　处：《临床血液学杂志》2021年第10期693-696,共4页Journal of Clinical Hematology

摘　　要：目的:分析血清胱抑素C(Cys-C)、β2-微球蛋白(β2-MG)、胎球蛋白A(Fetuin-A)与老年糖尿病肾病(DKD)的相关性。方法:究随机抽取2017年9月—2020年9收治的112例老年DKD患者为DKD组,同时选取接受治疗的100例老年单纯糖尿病(DM)患者为DM组,另选取100例老年体检者作为对照组,比较3组的血清Cys-C、β2-MG、Fetuin-A表达,分析Cys-C、β2-MG、Fetuin-A与尿微量清蛋白与肌酐比值(ACR)的相关性。结果:3组的Cys-C、β2-MG、Fetuin-A和ACR各项血清学指标比较,差异有统计学意义(P<0.05),组间比较显示DKD组和DM组患者的Cys-C、β2-MG、Fetuin-A和ACR表达水平均高于对照组(P<0.05),且DKD组的Cys-C、β2-MG、Fetuin-A和ACR高于DM组(P<0.05);相关性分析结果显示,血清Cys-C、β2-MG和Fetuin-A分别与ACR呈明显的正相关,相关性系数r值分别为0.819、0.928和0.867(P<0.05);Cys-C、β2-MG、Fetuin-A和联合诊断的曲线下面积(AUC)分别为0.778、0.922、0.828和0.982,联合检测的AUC明显高于其他指标的单独检测(P<0.05)。结论:血清Cys-C、β2-MG、Fetuin-A与DKD的发生和发展密切相关,相较于各指标的单独检测,Cys-C、β2-MG、Fetuin-A的联合检测有效实现对老年DKD的早期诊断和筛查。Objective: To analyze the relationship between serum cystatin C, β2-microglobulin, fetuin A and elderly diabetic nephropathy. Methods: We randomly selected 112 elderly patients with DKD admitted to our hospital from September 2017 to September 2020 as the DKD group, and selected 100 elderly patients with simple diabetes who were treated in the hospital as the DM group, and another 100 elderly physical examination subjects served as a control group. The serum Cys-C, β2-MG and Fetuin-A expressions of the three groups were compared, and the correlation between Cys-C, β2-MG, Fetuin-A and albumin to creatinine ratio(ACR) was analyzed. Results: The serum indexes of Cys-C, β2-MG, Fetuin-A and ACR in the three groups were significantly different(P<0.05). The comparison between the groups showed that the expression levels of Cys-C, β2-MG, Fetuin-A and ACR of the DKD group and the DM group were higher than those of the control group(P<0.05), and the Cys-C, β2-MG, Fetuin-A and ACR of the DKD group were higher than those of the DM group(P<0.05). The correlation analysis results showed that serum Cys-C, β2-MG and Fetuin-A were significantly positively correlated with ACR, and the correlation coefficient r values were 0.819, 0.928 and 0.867(P<0.05), respectively. The area under the curve(AUC) of Cys-C, β2-MG, Fetuin-A and combined diagnosis were 0.778, 0.922, 0.828 and 0.982, respectively. The AUC of combined detection was significantly higher than that of other indicators alone(P<0.05). Conclusion: Serum Cys-C, β2-MG, Fetuin-A are closely related to the occurrence and development of DKD. Compared with the independent detection of each index, the combined detection of Cys-C, β2-MG, Fetuin-A may be effectively early diagnosis and screening of elderly DKD.

关 键 词：胱抑素C Β2-微球蛋白 胎球蛋白A 糖尿病肾病 

分 类 号：R446.1[医药卫生—诊断学]