红细胞Diego血型抗原研究进展  

Research progress of erythrocyte Diego blood group antigen

作　　者：谢怡萍 李树中(审校)[1] 李中华 李凌波 田丰 XIE Yiping;LI Shuzhong;LI Zhonghua

机构地区：[1]江苏大学附属昆山医院,江苏昆山215300 [2]黑龙江省牡丹江市第二人民医院 [3]长春博讯生物技术有限责任公司 [4]江苏省昆山市第三人民医院

出　　处：《临床血液学杂志》2021年第10期746-752,共7页Journal of Clinical Hematology

摘　　要：Levine(1954年)和Layrise(1955年)报道了红细胞血型Diego抗原。抗原名取自先证者Diago夫人的名字(委内瑞拉)。1988年国际输血协会(ISBT)公布了Digeo抗原基因,并确认其属于独立的系统抗原,系统编号010。2019年ISBT再次确认该系统有22个抗原,其中高频抗原有3个,低频抗原有19个。Di a抗原被认为是一个只在蒙古人种呈多态性的抗原,在人类学的调查中,Di a抗原都有蒙古祖先血统的存在。Di抗原是一个重要的红细胞血型抗原,本文就Di抗原近年来的研究进展,做一简略综述;。Di aantigen is anthropologically related to the Mongolian race.The antigen gene is composed of 20 exons,and the translation product is Di glycoprotein/solute carrier transporter(SLC4 A1),also known as cell membrane band 3 protein(EPB-3),or“anion transporter”(AEI-7),also CD233.Di glycoprotein peptide chain passes through the cell membrane 14 times,leaving 7 loops outside the membrane.All Di system antigens are expressed on the outer membrane loop.Band 3 protein is one of the main components of erythrocyte membrane and skeleton.The lack of band 3 protein will lead to the collapse of red blood cells,which is clinically manifested as oval erythrocythemia in Southeast Asia.Di antigen can cause transfusion hemolysis and neonatal hemolytic disease,and is a clinically important blood group antigen.

关 键 词：溶质载体转运蛋白 带3蛋白 CD233 东南亚卵形红细胞血症 输血性溶血 

分 类 号：R457.1[医药卫生—治疗学]