COMT和DRD2基因多态性与运动认知风险综合征的关联研究  

Associations between Catechol-O-methyl transferase and dopamine receptor D2 gene polymorphism and risk of motoric cognitive risk syndrome

作　　者：宋奇 王西 张辉[1] 蒋晓燕[2] 王笑峰 SONG Qi;WANG Xi;ZHANG Hui;JIANG Xiao-yan;WANG Xiao-feng(School of Life Sciences,Fudan University,Shanghai 200433,China;不详)

机构地区：[1]复旦大学生命科学学院,上海200433 [2]同济大学医学院病理学与病理生理系 [3]复旦大学人类表型组研究院,上海200433

出　　处：《现代预防医学》2021年第22期4033-4036,共4页Modern Preventive Medicine

基　　金：国家重点研发计划(2018YFC2000400,2018YFC2002000)。

摘　　要：目的探讨儿茶酚-O-甲基转移酶(COMT)rs4680位点和多巴胺D2受体基因(DRD2)rs1800497位点与运动认知风险综合征(MCR)的关联。方法选取如皋衰老队列1 301名观察对象,并分为MCR组和非MCR组。通过Taqman MGB对COMT rs4680位点、DRD2 rs1800497位点进行基因分型,比较MCR组和非MCR组两位点的分布差异,并使用logistic回归分析估计位点对MCR的效应。结果 MCR组rs4680位点GA及AA基因型频率高于非MCR组(50%vs40.3%,10.2%vs 6.2%,P=0.023),MCR组A等位基因频率也高于非MCR组(35.2%vs 26.3%,P=0.005)。Logistic分析显示A等位基因及GA/AA基因型与MCR风险增加相关(OR=1.553,95%CI:1.131~2.133;OR=1.742,95%CI:1.144~2.655)。校正年龄、性别、BMI、吸烟史、饮酒史、教育程度、高血压、糖尿病、CRP后显著性依然存在。然而我们未发现rs1800497与MCR相关。结论 COMT rs4680多态性与中国老年人群MCR发生风险相关,rs4680 A等位基因可能是MCR发生的遗传易感因子。Objective To explore the relationship between polymorphism rs4680 of Catechol-O-methyl transferase and rs1800497 of dopamine receptor D2 gene rs1800497 and susceptibility to Motoric cognitive risk syndrome.Methods In total1 301 adults from Rugao Aging Cohort Study were selected and then divided into MCR group and Non-MCR group.Taqman MGB was used for genetic polymorphism detection.The allele and genotype frequencies were compared between MCR group and Non-MCR group.Logistic regression was used to explore the relationship between the gene polymorphism and MCR.Results In the MCR group,the GA and AA genotype frequencies of COMT rs4680 were higher than those in the Non-MCR group(50% vs 40.3%,10.2% vs 6.2%,P=0.023),and the A allele frequencies were also higher than those in the Non-MCR group(35.2% vs 26.3%,P=0.005).Compared with G allele and GG genotype,A allele and GA/AA genotype were the susceptibility allele or gene to MCR(OR=1.553,95%CI:1.131-2.133;OR=1.742,95%CI:1.144-2.655).After adjusting for multiple confounding factors,the significance remained.But rs100847 was not found to be associated with MCR.Conclusion The polymorphism of COMT rs4680 is associated with the risk of MCR in Chinese old people,and A allele may be the susceptible allele of MCR.

关 键 词：运动认知风险综合征 儿茶酚-O-甲基转移酶 多巴胺D2受体 基因多态性 

分 类 号：G804.2[文化科学—运动人体科学]