武进农村地区人群静息心率与2型糖尿病发病风险的队列研究  

A cohort study of resting heart rate and risk of type 2 diabetes in Wujin rural population

作　　者：宗菁 强德仁[1] 孔晓玲 石素逸[1] 杨佳成 闫于飘 储艳 ZONG Jing;QIANG De-ren;KONG Xiao-ling;SHI Su-yi;YANG Jia-cheng;YAN Yu-piao;CHU Yan(Wujin District of Changzhou Center for Disease Prevention and Control,Changzhou,Jiangsu 213161,China;不详)

机构地区：[1]常州市武进区疾病预防控制中心,江苏常州213161 [2]江苏大学附属武进医院 [3]徐州医科大学武进临床学院,江苏常州213002

出　　处：《现代预防医学》2021年第22期4104-4107,共4页Modern Preventive Medicine

基　　金：国家重点研发计划(2017YFC0907002);常州市武进区科技发展项目(WS201829)。

摘　　要：目的探讨武进农村地区成人静息心率与2型糖尿病发病风险的相关性。方法研究对象来源于2004—2005武进农村地区前瞻队列研究中35岁以上符合条件的10 066参与者。根据受试者基线静息心率的四分位数将其分为4组,第一组心率48~67次/min,第二组心率68~71次/min,第三组心率72~77次/min,第四组心率78~120次/min。调查内容包括问卷调查、体格检查和实验室检测。使用Cox比例风险模型分析静息心率与2型糖尿病发病之间的关系。结果经过平均7.35年的随访,共406例新发2型糖尿病,发病密度为5.49/1 000人年。Cox回归分析结果显示,在校正潜在混杂因素后,与第一组相比,第二、三、四组2型糖尿病发病风险比HR(95%CI)分别为1.75(1.26~2.45)、1.77(1.28~2.44)、1.85(1.34~2.54),静息心率与患2型糖尿病风险之间存在正相关(χ2趋势=15.98,P=0.001)。静息心率与年龄、体重指数(BMI)、是否吸烟、是否饮酒、有无糖尿病家族史在2型糖尿病发病风险中均不存在显著交互作用(P交互>0.05)。结论静息心率的升高与2型糖尿病发病风险增加显著相关,是2型糖尿病发病的独立危险因素。Objective To investigate the correlation between resting heart rate and the risk of developing type 2 diabetes mellitus in adults in rural areas of Wujin.Methods The study included 10 066 eligible participants aged 35 years or older in the 2004-2005 Wujin rural area prospective cohort study.The participants were divided into four groups according to the quartiles of their baseline resting heart rate:48-67 beats/min in the first group,68-71 beats/min in the second group,72-77 beats/min in the third group,and 78-120 beats/min in the fourth group.The survey included questionnaires,physical examination and laboratory tests.The relationship between resting heart rate and risk of type 2 diabetes was analyzed using a Cox proportional risk model.Results After a mean follow-up period of 7.35 years,406 new cases of type 2 diabetes were diagnosed,with an incidence of 5.49/1 000 person years.After adjusting for confounding factors,Cox regression analysis showed that the risk of incident type 2 diabetes was increased with quartiles 2,3 and 4 versus quartile 1 of resting heart rate,and the adjusted HRs(95% CIs) were 1.75(1.26-2.45),1.77(1.28-2.44),and 1.85(1.34-2.54),respectively.There was a positive association between resting heart rate and risk of developing type 2 diabetes mellitus(χ2 trend=15.98,P=0.001).There was no significant interaction between resting heart rate and age,BMI,smoking,alcohol consumption,and family history in relation to risk of type 2 diabetes(P for interaction >0.05).Conclusion Increased resting heart rate is significantly associated with increased risk of developing type 2 diabetes and is an independent risk factor for the development of type 2 diabetes.

关 键 词：静息心率 2型糖尿病 队列研究 

分 类 号：R587.1[医药卫生—内分泌]